Neurobiology is in a period of explosive growth and change. The development of new techniques, the application of advances in genetics and immunology, the influx of talented scientists from other areas of biomedical science, and the increasing conviction that the time is ripe for major advances in neurobiology, have led to a period of unprecedented growth. Rapid progress will undoubtedly continue through the next decade and will bring major payoffs. Progress in neurobiological research will lead not only to greater understanding of the brain, but will lay the foundation for new modes of diagnosis, treatment and management of neurological and psychiatric disease. Child Neurology deals with illnesses that are among the most debilitating and expensive, and yet this discipline is among the least touched by the modern revolution in biology. Individuals trained in both clinical and basic neuroscience would provide the most effective bridge between disciplines, and could translate basic neuroscience advances into new approaches for understanding and treating neurological diseases in children. This application proposes to develop such individuals through the creation of a research training program for Child Neurology residents at UCSF. The program would integrate clinical and research activities of selected residents in a coherent plan for career development. An effective training program must provide broad and rigorous exposure to ideas and techniques that transcend the bounds of traditional disciplines. We propose to achieve this goal by developing for each trainee a program that incorporates rich experiences in both basic and clinical neuroscience. Clinical training activities will be carried out in the Division of Child Neurology where trainees will become experienced, thoughtful clinicians able to bring critical thinking to bear on clinical problems. Basic science training will consist of both didactic and research activities to be carried out over a minimum of two years. Research training will be carried out in the laboratory of mentors who are established neuroscientists, representing a variety of disciplines, who are committed to trainee development. Formal and informal didactic activities will be carried out under the umbrella of the UCSF Neuroscience Program. The PI and his Advisory Committee will be responsible for candidate recruitment and trainee selection, monitoring of trainee progress, and support of the trainee's transition to an independent research career. A successful training program will result in the production of a number of highly talented Child Neurologist- neuroscientists who pursue productive investigative careers that impact significantly on neurological disease in children.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12NS001692-05
Application #
2445649
Study Section
NST-2 Subcommittee (NST)
Program Officer
Hirtz, Deborah G
Project Start
1993-07-01
Project End
2004-06-30
Budget Start
1997-07-01
Budget End
2004-06-30
Support Year
5
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Neurology
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Mao, Cheng-Jie; Yang, Ya-Ping; Chen, Ju-Ping et al. (2018) Poor nighttime sleep is positively associated with dyskinesia in Parkinson's disease patients. Parkinsonism Relat Disord 48:68-73
Rice, Gillian I; Kitabayashi, Naoki; Barth, Magalie et al. (2017) Genetic, Phenotypic, and Interferon Biomarker Status in ADAR1-Related Neurological Disease. Neuropediatrics 48:166-184
Fox, Christine K; Glass, Hannah C; Sidney, Stephen et al. (2016) Neonatal seizures triple the risk of a remote seizure after perinatal ischemic stroke. Neurology 86:2179-86
Papinutto, Nico; Galantucci, Sebastiano; Mandelli, Maria Luisa et al. (2016) Structural connectivity of the human anterior temporal lobe: A diffusion magnetic resonance imaging study. Hum Brain Mapp 37:2210-22
Fox, Christine K; Sidney, Stephen; Fullerton, Heather J (2015) Community-based case-control study of childhood stroke risk associated with congenital heart disease. Stroke 46:336-40
Gelfand, Amy A; Goadsby, Peter J; Allen, I Elaine (2015) The relationship between migraine and infant colic: a systematic review and meta-analysis. Cephalalgia 35:63-72
Gelfand, Amy A; Fullerton, Heather J; Jacobson, Alice et al. (2015) Is migraine a risk factor for pediatric stroke? Cephalalgia 35:1252-60
Gelfand, Amy A; Goadsby, Peter J (2014) Medication overuse in children and adolescents. Curr Pain Headache Rep 18:428
Gelfand, Amy A; Reider, Amanda C; Goadsby, Peter J (2014) Outcomes of greater occipital nerve injections in pediatric patients with chronic primary headache disorders. Pediatr Neurol 50:135-9
Mueller, Sabine; Hashizume, Rintaro; Yang, Xiaodong et al. (2014) Targeting Wee1 for the treatment of pediatric high-grade gliomas. Neuro Oncol 16:352-60

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