The aim of our interdisciplinary Institutional Neurological Sciences Academic Development Award (NSADA) Program, based at The Children's Hospital of Philadelphia (CHOP) and The University of Pennsylvania (U of P), is to train child neurologists with a MD or MD/PhD to flourish in academia as clinician scientists. Our long-term goals are for our trainees to establish the foundations of basic and clinical research as it pertains to childhood neurological diseases. This will enable our graduates to make Inroads to our understanding of disease processes, and then for others to take these scientific observations to the "bedside" by conducting well-designed clinical trials. 39 mentors will participate in this first competitive renewal of this program;18 are based primarily at CHOP, and 21 primarily at the U of P. All are heavily involved in biomedical graduate education and are closely interlinked by mutual research projects and grants. In addition to mentored research training, our curriculum emphasizes: 1) formal course work through the U of P Graduate Studies Program, 2) when appropriate, enroll in the Masters in Statistics and Clinical Epidemiology through the CCEB program at U of P, 3) training in responsible conduct of research, 4) training In biostatistics, and 5) workshops that cover a variety of important survival skills. Including scientific writing, public presentations, grant writing workshops, laboratory management and career advancement skills. During the first 4 years of our program, we accepted 4 trainees;2 were MDs, and 2 were MD/PhDs. Two of these trainees were female. The two candidates in years 1 and 2 are on the faculty at U of P as Assistant Professors, and the other two are Instructors also at U of P. We request continued support for 1 child neurologist/year to be a NSADA candidate. Our goal remains focused on providing a training program unlike any other here at CHOP or U of P that is focused on child neurologists to acquire the necessary training that will enable them to be outstanding clinicians/scientists. This program benefits from being in an outstanding environment that commits substantial resources to training, to basic biomedical research, and to a true 'bench to bedside" approach to translational research.

Public Health Relevance

There is a serious shortage of clinicians/scientists in the child neurology workforce in the USA, Clinicians and scientists are urgently needed to apply modern methods to elucidate the pathogenesis and pathophysiology of neurological disorders, and to train individuals to translate this information into patient care, so that new and more effective therapeutic interventions can be identified. This program strives to fill this need.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12NS049453-08
Application #
8509795
Study Section
Special Emphasis Panel (ZNS1-SRB-M (74))
Program Officer
Korn, Stephen J
Project Start
2004-07-01
Project End
2016-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
8
Fiscal Year
2013
Total Cost
$460,728
Indirect Cost
$45,504
Name
Children's Hospital of Philadelphia
Department
Type
DUNS #
073757627
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Zhou, Jian; Goldberg, Ethan M; Leu, N Adrian et al. (2014) Respiratory failure, cleft palate and epilepsy in the mouse model of human Xq22.1 deletion syndrome. Hum Mol Genet 23:3823-9
Beslow, Lauren A; Ichord, Rebecca N; Gindville, Melissa C et al. (2014) Frequency of hematoma expansion after spontaneous intracerebral hemorrhage in children. JAMA Neurol 71:165-71
Beslow, Lauren A; Ichord, Rebecca N; Gindville, Melissa C et al. (2014) Pediatric intracerebral hemorrhage score: a simple grading scale for intracerebral hemorrhage in children. Stroke 45:66-70
Bruno, Christie J; Beslow, Lauren A; Witmer, Char M et al. (2014) Haemorrhagic stroke in term and late preterm neonates. Arch Dis Child Fetal Neonatal Ed 99:F48-53
Adil, Malik M; Qureshi, Adnan I; Beslow, Lauren A et al. (2014) Transient ischemic attack requiring hospitalization of children in the United States: kids' inpatient database 2003 to 2009. Stroke 45:887-8
Goksun, Tilbe; Woods, Adam J; Chatterjee, Anjan et al. (2013) Elementary school children's attentional biases in physical and numerical space. Eur J Dev Psychol 10:433-448
Abend, Nicholas S; Wusthoff, Courtney J; Goldberg, Ethan M et al. (2013) Electrographic seizures and status epilepticus in critically ill children and neonates with encephalopathy. Lancet Neurol 12:1170-9
Beslow, Lauren A; Abend, Nicholas S; Gindville, Melissa C et al. (2013) Pediatric intracerebral hemorrhage: acute symptomatic seizures and epilepsy. JAMA Neurol 70:448-54
Beslow, Lauren A; Kasner, Scott E; Smith, Sabrina E et al. (2012) Concurrent validity and reliability of retrospective scoring of the Pediatric National Institutes of Health Stroke Scale. Stroke 43:341-5
Lang, Shih-Shan; Beslow, Lauren A; Bailey, Robert L et al. (2012) Follow-up imaging to detect recurrence of surgically treated pediatric arteriovenous malformations. J Neurosurg Pediatr 9:497-504

Showing the most recent 10 out of 31 publications