The research is based on the hypothesis that the zinc metalloendoprotease, bone morphogenetic protein-1 (BMP-1), activates the growth factors, BMP-2 and -4. The immediate goals of the research project are to express BMP-1 and characterize the protease. Both the physical properties and kinetic parameters will be investigated. Knowledge of these parameters will facilitate subsequent examination of BMP-1 expression and function in the dental pulp tissue.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Unknown (K15)
Project #
1K15DE000373-01
Application #
2128838
Study Section
NIDCR Special Grants Review Committee (DSR)
Project Start
1995-04-01
Project End
2000-03-31
Budget Start
1995-04-01
Budget End
1996-03-31
Support Year
1
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Pennsylvania State University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033