Geometric Approximation of the Growth of the Optic Nerve/Globe Complex Surgical manipulation of the optic nerve/globe complex is limited to only slight mediolateral movement about the optic foramen; therefore, the normal relationship of this complex to the bony orbit is of prime importance for the planning and correction of craniofacial anomalies. This study applied geometric formulas on pre-existing orbital growth data in order to approximate the two dimensional normal development of the optic nerve/globe complex. Five linear and four angular dimensions were followed from birth to 15 years of age. The means and ranges at each age interval were examined in order to describe the growth patterns associated with the optic nerve/globe complex. From this scalar information, a spatial map of the complex was created. Of the orbital dimensions observed, the optic nerve axis length, the optic nerve/globe length and the orbit axis length displayed similar patterns of growth with rapid development occurring in the first 3 years of life followed by a slower rate of growth through puberty. All four angular dimensions, the interorbital angle, the orbit axis angle, the optic nerve axis angle and the pupil/orbital rim angle revealed negligible development from birth to 15 years of age. The two linear dimensions describing the width of the orbit, the pupil/orbital rim width and the orbital width, exhibited similar characteristics in development. Both dimensions grew at moderate rates during the first 2 years after birth, followed by slower rates of growth through age 15 years. Quantitative knowledge of the growth of the optic nerve/globe complex is a tool which could boost the accuracy of pre-operative treatment planning, intra-operative manipulation and post-operative evaluation. Ultimately, quantitative intervention will lead to greater predictability of functional and esthetic results. Keywords: craniofacial anomalies, optic nerve/globe complex

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Unknown (K16)
Project #
5K16DE000275-04
Application #
3775639
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Harvard University
Department
Type
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
McDermott, Nancy E; Chuang, Sung-Kiang; Woo, Valerie V et al. (2006) Maxillary sinus augmentation as a risk factor for implant failure. Int J Oral Maxillofac Implants 21:366-74
Chuang, S K; Cai, T; Douglass, C W et al. (2005) Frailty approach for the analysis of clustered failure time observations in dental research. J Dent Res 84:54-8
Chuang, S-K; Hatch, J P; Rugh, J et al. (2005) Multi-center randomized clinical trials in oral and maxillofacial surgery: modeling of fixed and random effects. Int J Oral Maxillofac Surg 34:341-4
Treister, Nathaniel S; Woo, Sook-Bin; O'Holleran, Eileen W et al. (2005) Oral chronic graft-versus-host disease in pediatric patients after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 11:721-31
Woo, Valerie V; Chuang, Sung-Kiang; Daher, Shadi et al. (2004) Dentoalveolar reconstructive procedures as a risk factor for implant failure. J Oral Maxillofac Surg 62:773-80
Halpern, Leslie R; Carter, Jeffrey B; Chuang, Sung-Kiang et al. (2003) A comparison of 2 consultation and treatment strategies to manage impacted third molars. J Oral Maxillofac Surg 61:779-84
Basile, John R; Eichten, Alexandra; Zacny, Valerie et al. (2003) NF-kappaB-mediated induction of p21(Cip1/Waf1) by tumor necrosis factor alpha induces growth arrest and cytoprotection in normal human keratinocytes. Mol Cancer Res 1:262-70
McDermott, Nancy E; Chuang, Sung-Kiang; Woo, Valerie V et al. (2003) Complications of dental implants: identification, frequency, and associated risk factors. Int J Oral Maxillofac Implants 18:848-55
Chuang, S K; Tian, L; Wei, L J et al. (2002) Predicting dental implant survival by use of the marginal approach of the semi-parametric survival methods for clustered observations. J Dent Res 81:851-5
Chuang, S K; Wei, L J; Douglass, C W et al. (2002) Risk factors for dental implant failure: a strategy for the analysis of clustered failure-time observations. J Dent Res 81:572-7

Showing the most recent 10 out of 32 publications