HIV-1 is the causative agent of acquired immune deficiency syndrome [AIDS];however emerging evidence implicates HIV-1 in a broader illness that includes systemic immune system activation. This study will determine the mechanism of HIV-1-induced macrophage activation while also developing novel approaches to suppress harmful inflammation. The findings of this study will directly impact human health by bringing about changes to current HIV-1 therapy regimens to include drugs that treat inflammation while still striving to suppress HIV-1 replication. The scientific goals of the proposed study support my career goals by providing a basis for long-term funding and a pathway to independence.
|Appelberg, K Sofia; Wallet, Mark A; Taylor, Jared P et al. (2017) HIV-1 Infection Primes Macrophages Through STAT Signaling to Promote Enhanced Inflammation and Viral Replication. AIDS Res Hum Retroviruses 33:690-702|
|Wallet, Mark A; Buford, Thomas W; Joseph, Anna-Maria et al. (2015) Increased inflammation but similar physical composition and function in older-aged, HIV-1 infected subjects. BMC Immunol 16:43|
|Wallet, Mark A; Reist, Caroline M; Williams, Julie C et al. (2012) The HIV-1 protease inhibitor nelfinavir activates PP2 and inhibits MAPK signaling in macrophages: a pathway to reduce inflammation. J Leukoc Biol 92:795-805|