Density-dependent nuclear accumulation of VEGF-D similar to that in cultured cells was observed with fibroblasts in fibrotic areas of human lung suggests that nuclear VEGF-D plays an important role in fibroblast homeostasis In vivo, particularly perhaps in fibrotic lung disease. As VEGF-D processing is known to result from actions of furin and protein conve^rtase (PC)-5, manipulation of VEGF-D processing might produce desirable therapeutic effects on its nuclear trafficking and biological function with potential clinical application.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Career Transition Award (K22)
Project #
5K22HL092223-03
Application #
8545893
Study Section
Special Emphasis Panel (NSS)
Program Officer
Colombini-Hatch, Sandra
Project Start
2008-06-01
Project End
2013-06-30
Budget Start
2013-04-01
Budget End
2013-06-30
Support Year
3
Fiscal Year
2013
Total Cost
$162,000
Indirect Cost
$12,000
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115