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Public Health Relevance

The scientific goal of this grant is to gain a better understanding of the mechanisms responsible for regulating the structure of chromatin and to furthermore explore how this regulation is involved in development. This research will lead to a greater understanding of developmental processes in general, with specific applications to hematopoietic development. Relevance These studies will further elucidate how components responsible for packaging the genome into the nucleus interact with other proteins to regulate gene expression. These insights will shed further light on gene regulation and developmental processes in general.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Career Transition Award (K22)
Project #
5K22HL101950-03
Application #
8253686
Study Section
Special Emphasis Panel (NSS)
Program Officer
Carlson, Drew E
Project Start
2011-04-06
Project End
2014-03-31
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
3
Fiscal Year
2012
Total Cost
$268,920
Indirect Cost
$19,920
Name
City of Hope/Beckman Research Institute
Department
Type
DUNS #
027176833
City
Duarte
State
CA
Country
United States
Zip Code
91010
Leung, Amy; Parks, Brian W; Du, Juan et al. (2014) Open chromatin profiling in mice livers reveals unique chromatin variations induced by high fat diet. J Biol Chem 289:23557-67
Jose, Cynthia C; Xu, Beisi; Jagannathan, Lakshmanan et al. (2014) Epigenetic dysregulation by nickel through repressive chromatin domain disruption. Proc Natl Acad Sci U S A 111:14631-6
Zhang, Shaofei; Schones, Dustin E; Malicet, Cedric et al. (2013) High mobility group protein N5 (HMGN5) and lamina-associated polypeptide 2? (LAP2?) interact and reciprocally affect their genome-wide chromatin organization. J Biol Chem 288:18104-9
Leung, Amy; Trac, Candi; Jin, Wen et al. (2013) Novel long noncoding RNAs are regulated by angiotensin II in vascular smooth muscle cells. Circ Res 113:266-78
Hu, Gangqing; Schones, Dustin E; Cui, Kairong et al. (2011) Regulation of nucleosome landscape and transcription factor targeting at tissue-specific enhancers by BRG1. Genome Res 21:1650-8