Sixty percent of all cancer and seventy percent of cancer mortality occurs in people over age 65. As the population ages, there is an emerging need to develop a means for oncologists to characterize the "functional age" of older patients with cancer in order to tailor treatment decisions and stratify outcomes based on factors other than chronological age and to develop interventions to optimize cancer treatment. HYPOTHESIS: A geriatric instrument for older patients with cancer can be formulated to identify factors independent of age that predict cancer treatment morbidity and mortality and result in rationale interventions to optimize oncologic care.
SPECIFIC AIMS : 1) To determine the generalized feasibility and psychometric properties of a newly developed geriatric instrument for older patients with cancer; 2) To assess the geriatric instrument's ability to predict which older patients are more vulnerable to toxicity from chemotherapy; and 3) To determine the impact of the geriatric instrument on clinical care and overall outcomes through specific interventions. CAREER DEVELOPMENT: Through this work, the candidate will meld her previous training in geriatrics and oncology and develop the skills needed to develop an independent research career in geriatric oncology. Five years of didactic coursework in clinical trial design, biostatistics, and measurement development are planned. The candidate will be mentored by experts in the fields of oncology (Dr. George Bosl, Mentor), geriatrics (Dr. Mark Lachs, Co-Mentor), psychosocial research (Dr. Alice Kornblith, Advisor), and biostatistics (Dr. Katherine Panageas and Dr. Bercedis Peterson, collaborators). Through this career development award, the applicant will acquire the skills necessary to pursue an independent research career in geriatric oncology. Through the support of this grant, the candidate aims to further knowledge about geriatric oncology, and thus enhance the health and independence as well as the quality of life of older Americans with cancer.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23AG026749-04
Application #
7262611
Study Section
Special Emphasis Panel (ZAG1-ZIJ-9 (M3))
Program Officer
Yancik, Rosemary
Project Start
2005-08-15
Project End
2010-07-31
Budget Start
2007-08-01
Budget End
2008-07-31
Support Year
4
Fiscal Year
2007
Total Cost
$182,314
Indirect Cost
Name
City of Hope/Beckman Research Institute
Department
Type
DUNS #
027176833
City
Duarte
State
CA
Country
United States
Zip Code
91010
Hurria, Arti; Mohile, Supriya; Gajra, Ajeet et al. (2016) Validation of a Prediction Tool for Chemotherapy Toxicity in Older Adults With Cancer. J Clin Oncol 34:2366-71
Cohen, Harvey Jay; Smith, David; Sun, Can-Lan et al. (2016) Frailty as determined by a comprehensive geriatric assessment-derived deficit-accumulation index in older patients with cancer who receive chemotherapy. Cancer 122:3865-3872
Owusu, Cynthia; Cohen, Harvey Jay; Feng, Tao et al. (2015) Anemia and Functional Disability in Older Adults With Cancer. J Natl Compr Canc Netw 13:1233-9
Weiss Wiesel, Talia R; Nelson, Christian J; Tew, William P et al. (2015) The relationship between age, anxiety, and depression in older adults with cancer. Psychooncology 24:712-7
Gajra, Ajeet; Klepin, Heidi D; Feng, Tao et al. (2015) Predictors of chemotherapy dose reduction at first cycle in patients age 65 years and older with solid tumors. J Geriatr Oncol 6:133-40
Maggiore, Ronald J; Dale, William; Gross, Cary P et al. (2014) Polypharmacy and potentially inappropriate medication use in older adults with cancer undergoing chemotherapy: effect on chemotherapy-related toxicity and hospitalization during treatment. J Am Geriatr Soc 62:1505-12
Mohile, Supriya G; Hardt, Molly; Tew, William et al. (2013) Toxicity of bevacizumab in combination with chemotherapy in older patients. Oncologist 18:408-14
Won, Elizabeth; Hurria, Arti; Feng, Tao et al. (2013) CA125 level association with chemotherapy toxicity and functional status in older women with ovarian cancer. Int J Gynecol Cancer 23:1022-8
Hurria, Arti (2012) Communicating treatment options to older patients: challenges and opportunities. J Natl Compr Canc Netw 10:1174-6
Maggiore, Ronald J; Gross, Cary P; Togawa, Kayo et al. (2012) Use of complementary medications among older adults with cancer. Cancer 118:4815-23

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