As people age into their 80's and 90's they become more heterogeneous in terms of their health and recommendations for health promotion must be individualized. More data on the benefits and risks of many health promotion measures for women aged 80 and older are necessary to help clinicians target use of these measures to those women most likely to benefit. The projects proposed in this application focus on the benefits and burdens of mammography screening for women aged 80 and older. In the future, Dr. Schonberg plans to use the skills she obtains from this career development award to explore the benefits and risks of other screening tests and health promotion measures for elderly women. Dr. Schonberg proposes two related and complementary projects to gather data on the benefits and burdens of mammography screening for women aged 80 or older. For the first project she will use data from the linked Surveillance, Epidemiology and End Results (SEER) registry-Medicare database to describe breast cancer tumor characteristics, stage-specific treatments, and survival of women aged 80 and older newly diagnosed with breast cancer, and compare these with women aged 66 to 79 after considering health and proxies for socioeconomic status. The second project is a pilot longitudinal observational study to describe the psychological impact and the decision-making process after an abnormal mammogram of women aged 80 and older compared to women aged 65-79. Through coursework, seminars, and the development and completion of these rigorous studies, Dr. Schonberg plans to enhance her methodological skills and understanding of geriatric principles; learn to work with Medicare and other claims data and to perform longitudinal and survival analyses; develop expertise in psychometric testing and assessing elderly women's medical decision-making; and collect data that can be used to create tools to help women aged 80 or older and their clinicians make decisions around mammography screening. This career development award will allow Dr. Schonberg to acquire additional research skills and expertise and to collect data to aid decision- making around breast cancer screening, diagnosis, and treatment among women aged 80 and older. It will also further her long-term career goal to become a skilled and established independent investigator in the area of disease prevention and health promotion for the oldest-old. ? ? ? ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23AG028584-02
Application #
7448457
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Haaga, John G
Project Start
2007-09-01
Project End
2012-08-31
Budget Start
2008-09-01
Budget End
2009-08-31
Support Year
2
Fiscal Year
2008
Total Cost
$156,532
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02215
Schonberg, Mara A; Birdwell, Robyn L; Bychkovsky, Brittany L et al. (2014) Older women's experience with breast cancer treatment decisions. Breast Cancer Res Treat 145:211-23
Schonberg, Mara A; Hamel, Mary Beth; Davis, Roger B et al. (2014) Development and evaluation of a decision aid on mammography screening for women 75 years and older. JAMA Intern Med 174:417-24
Schonberg, Mara A; Silliman, Rebecca A; Ngo, Long H et al. (2014) Older women's experience with a benign breast biopsy—a mixed methods study. J Gen Intern Med 29:1631-40
Walter, Louise C; Schonberg, Mara A (2014) Screening mammography in older women: a review. JAMA 311:1336-47
Schonberg, Mara A; Breslau, Erica S; McCarthy, Ellen P (2013) Targeting of mammography screening according to life expectancy in women aged 75 and older. J Am Geriatr Soc 61:388-95
Schonberg, Mara A; Walter, Louise C (2013) Talking about stopping cancer screening-not so easy. JAMA Intern Med 173:532-3
Schonberg, Mara A; Marcantonio, Edward R; Ngo, Long et al. (2012) Does Life Expectancy Affect Treatment of Women Aged 80 and Older with Early Stage Breast Cancers? J Geriatr Oncol 3:8-16
Schonberg, Mara A; Silliman, Rebecca A; McCarthy, Ellen P et al. (2012) Factors noted to affect breast cancer treatment decisions of women aged 80 and older. J Am Geriatr Soc 60:538-44
Schonberg, Mara A; Davis, Roger B; McCarthy, Ellen P et al. (2011) External validation of an index to predict up to 9-year mortality of community-dwelling adults aged 65 and older. J Am Geriatr Soc 59:1444-51
Schonberg, Mara A; Marcantonio, Edward R; Ngo, Long et al. (2011) Causes of death and relative survival of older women after a breast cancer diagnosis. J Clin Oncol 29:1570-7

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