The purpose of this application is to support the patient-oriented research program and career development of Vineet Arora, MD, MA, a fellowship-trained academic hospitalist at the University of Chicago. Dr. Arora's overall goal is to develop into an independent investigator with a focus on characterizing and improving sleep duration and sleep quality for older hospitalized patients. Dr. Arora will develop her research skills under the mentorship of Eve Van Cauter, PhD, a well-known authority on sleep and circadian rhythms in normal and pathologic states, with a focus on sleep in older persons. David Meltzer, MD, PhD, an accomplished investigator in research in hospital medicine and health economics with a focus on aging, will serve as a co- mentor. Dr. Arora will also benefit from the collective expertise in clinical care and research of older persons from a team of advisors, including Drs. Greg Sachs, Eric Coleman, and Daniel Brauner. She will also obtain necessary training and research skills from a team of collaborators including: (1) Babak Mokhlesi, MD, Director of the Sleep Medicine Fellowship, who will enable Dr. Arora to obtain formal training in sleep medicine;(2) Kristen Knutson, PhD, a research faculty and anthropologist who specializes in the use of actigraphy and sleep scales to quantify sleep duration and quality;and (3) Anirban Basu, PhD, an expert in statistical analysis. During the proposed award, Dr. Arora will obtain formal training in sleep medicine, health services research, and geriatrics through structured curricula and coursework at the University of Chicago. The overall goal of this research proposal is to elucidate how environmental, healthcare, and patient factors, in addition to a patients'level of perceived control, impact sleep duration and sleep quality in hospitalized older patients. In addition, the relationship between inpatient sleep (duration and quality) and outcomes (physical activity and other health outcomes) for hospitalized older patients will be characterized. Through this period of career development and research, Dr. Arora will be able to better understand the determinants and effects of in- hospital sleep which can enable the design of evidence-based interventions that aim to improve in-hospital sleep and associated outcomes for hospitalized older adults.

Public Health Relevance

The overall goal of this research proposal is to elucidate how environmental, healthcare, and patient factors, in addition to a patients'level of perceived control, impact sleep duration and sleep quality in hospitalized older patients. In addition, the relationship between inpatient sleep (duration and quality) and outcomes (physical activity and other health outcomes) for hospitalized older patients will be characterized. Through this period of career development and research, Dr. Arora will be able to better understand the determinants and effects of in-hospital sleep which can enable the design of evidence-based interventions that aim to improve in-hospital sleep and associated outcomes for hospitalized older adults.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23AG033763-05
Application #
8528439
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Mackiewicz, Miroslaw
Project Start
2009-09-30
Project End
2014-08-31
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
5
Fiscal Year
2013
Total Cost
$152,256
Indirect Cost
$11,278
Name
University of Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Press, Valerie G; Arora, Vineet M; Trela, Kristin C et al. (2016) Effectiveness of Interventions to Teach Metered-Dose and Diskus Inhaler Techniques. A Randomized Trial. Ann Am Thorac Soc 13:816-24
Press, Valerie G; Matthiesen, Madeleine I; Ranadive, Alisha et al. (2015) Insights into inpatients with poor vision: A high value proposition. J Hosp Med 10:311-3
Beveridge, Claire; Knutson, Kristen; Spampinato, Lisa et al. (2015) Daytime Physical Activity and Sleep in Hospitalized Older Adults: Association with Demographic Characteristics and Disease Severity. J Am Geriatr Soc 63:1391-400
Calev, Hila; Spampinato, Lisa M; Press, Valerie G et al. (2015) Prevalence of impaired memory in hospitalized adults and associations with in-hospital sleep loss. J Hosp Med 10:439-45
Hougham, Gavin W; Ham, Sandra A; Ruhnke, Gregory W et al. (2014) Sequence patterns in the resolution of clinical instabilities in community-acquired pneumonia and association with outcomes. J Gen Intern Med 29:563-71
Yoder, Jordan C; Arora, Vineet M; Edelson, Dana P (2014) Acutely ill patients will likely benefit from more monitoring, not less--reply. JAMA Intern Med 174:475-6
Arora, Vineet M; Berhie, Saba; Horwitz, Leora I et al. (2014) Using standardized videos to validate a measure of handoff quality: the handoff mini-clinical examination exercise. J Hosp Med 9:441-6
Shear, Talia C; Balachandran, Jay S; Mokhlesi, Babak et al. (2014) Risk of sleep apnea in hospitalized older patients. J Clin Sleep Med 10:1061-6
Horwitz, Leora I; Rand, David; Staisiunas, Paul et al. (2013) Development of a handoff evaluation tool for shift-to-shift physician handoffs: the Handoff CEX. J Hosp Med 8:191-200
Yoder, Jordan C; Yuen, Trevor C; Churpek, Matthew M et al. (2013) A prospective study of nighttime vital sign monitoring frequency and risk of clinical deterioration. JAMA Intern Med 173:1554-5

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