In the last decade, per capita prescription drug use in the U.S. more than doubled. Americans over 65 now consume an average of 28 prescriptions per year. My preliminary analyses show that in 2007, the average Medicare Part D enrollee received more than 43 30-day prescription fills. While polypharmacy is increasingly common, research on this topic is surprisingly sparse. Evidence demonstrates important adverse outcomes associated with polypharmacy and suggests that older adults may be particularly susceptible to medication-associated adverse outcomes due to their relative frailty, chronicity of treatment and multiple morbidities. Medications are credited with enhanced quality and length of life and averting use of other health services, but as drug use expands, the challenge is to achieve balance between benefits and risks. As a junior investigator, my long-term career goal is to become a leading researcher on causes and consequences of polypharmacy among older adults. The career development aims of this proposal are: (1) to develop the experience, skills, and advanced statistical methods and models necessary for effective and efficient analysis of merged claims from Medicare parts A, B and D;and (2) to develop expertise, pilot data, and collaborative relationships necessary to advance toward independent funding and a career as a leader in the field of geriatric pharmacoepidemiology. To advance these career aims, I propose a mentored study of fractures associated with exposure to multiple medication classes individually associated with fracture. The specific research aims are: (1) to characterize fracture-promoting prescription drug use among Medicare Part D enrollees;(2) to explore individual and system-specific determinants of prescription drug use intensity;and (3) to quantify the association between fracture-promoting polypharmacy and fracture. This topic directly addresses high-priority research areas of the NIA Geriatrics Branch, specifically, """"""""effects of comorbidity and polypharmacy"""""""" and """"""""multifactorial geriatric syndromes;"""""""" and will lead to R01 applications for continued study of the causes and consequences of geriatric polypharmacy.

Public Health Relevance

Studies assessing the effects of medication combinations are necessary to ensure safe and effective use of prescription drugs. This is especially important for older adults who may be particularly susceptible to additive side effects when using many different medicines. I will begin this work through study of fractures associated with use of multiple medicines known to increase fracture risk.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Mentored Patient-Oriented Research Career Development Award (K23)
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National Institute on Aging Initial Review Group (NIA)
Program Officer
Salive, Marcel
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Dartmouth College
Public Health & Prev Medicine
Schools of Medicine
United States
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Schpero, William L; Morden, Nancy E; Sequist, Thomas D et al. (2017) For Selected Services, Blacks And Hispanics More Likely To Receive Low-Value Care Than Whites. Health Aff (Millwood) 36:1065-1069
Colla, Carrie H; Sequist, Thomas D; Rosenthal, Meredith B et al. (2015) Use of non-indicated cardiac testing in low-risk patients: Choosing Wisely. BMJ Qual Saf 24:149-53
Colla, Carrie H; Lewis, Valerie A; Beaulieu-Jones, Brendin R et al. (2015) Role of pharmacy services in accountable care organizations. J Manag Care Spec Pharm 21:338-44
Morden, N E; Munson, J C; Smith, J et al. (2015) Oral bisphosphonates and upper gastrointestinal toxicity: a study of cancer and early signals of esophageal injury. Osteoporos Int 26:663-72
Bekelis, Kimon; Smith, Jeremy; Zhou, Weiping et al. (2015) Statins and subarachnoid hemorrhage in Medicare patients with unruptured cerebral aneurysms. Int J Stroke 10 Suppl A100:38-45
Colla, Carrie H; Morden, Nancy E; Sequist, Thomas D et al. (2015) Choosing wisely: prevalence and correlates of low-value health care services in the United States. J Gen Intern Med 30:221-8
Liu, Stephen K; Munson, Jeffrey C; Bell, John-Erik et al. (2014) Response letter to Herbert L. Muncie, Jr. J Am Geriatr Soc 62:998-9
Morden, N E; Schpero, W L; Zaha, R et al. (2014) Overuse of short-interval bone densitometry: assessing rates of low-value care. Osteoporos Int 25:2307-11
Morden, Nancy E; Munson, Jeffrey C; Colla, Carrie H et al. (2014) Prescription opioid use among disabled Medicare beneficiaries: intensity, trends, and regional variation. Med Care 52:852-9
Morden, Nancy E; Colla, Carrie H; Sequist, Thomas D et al. (2014) Choosing wisely--the politics and economics of labeling low-value services. N Engl J Med 370:589-92

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