As the population continues to age, the incidence of dementia and Alzheimer's disease (AD) is dramatically increasing, resulting in an urgent need to identify those older adults at risk for unhealthy brain aging and dementia. Mild cognitive impairment (MCI) is a well-accepted prodromal phase of AD. Because as many as 60% of individuals with MCI convert to AD within a three-year period, early identification of MCI is becoming increasingly important. Unfortunately, estimates suggest that at least half of individuals with MCI go undiagnosed in the community. Many barriers at the primary care level are associated with under-diagnosis of MCI, including insufficient time to assess cognition and lack of efficient screening tools available for use in primary care. To overcome these barriers, the current study will examine the nature of cognitive complaints within the community in order to develop a valid and reliable cognitive complaint measure for community-based older adults. Information from the proposed study will provide a cost-effective and time-efficient tool to aid in assessment and referral decisions for primary care patients in need of a more comprehensive memory work-up. Using a case-control cohort, we will validate a set of questions that reliably measure cognitive complaint with respect to differential diagnosis and in relation to objective cognitive performance, neuroanatomical changes, and biomarker levels. Mentored training activities will focus on latent variable modeling, neuroimaging principles in aging research, clinical implementation of psychological tools within the community, and professional development. The proposed study and training will leverage an interdisciplinary team (including neuropsychology, geriatrics, neurology, neuroradiology, and biostatistics) as well as resources associated with the Vanderbilt Memory & Alzheimer's Center, the Vanderbilt University Institute of Imaging Science, and the Vanderbilt University Department of Biostatistics to fulfill the aims outlined.

Public Health Relevance

Alzheimer's disease (AD) is an increasingly important public health issue with the rapid aging of the population. Early detection of mild cognitive impairment (MCI), the prodromal phase of AD, is an important step in managing this growing public health crisis, particularly as effective prevention strategies and therapeutic targets become available.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
1K23AG045966-01A1
Application #
8966527
Study Section
Special Emphasis Panel (ZAG1-ZIJ-6 (M2))
Program Officer
Silverberg, Nina B
Project Start
2015-09-01
Project End
2020-05-31
Budget Start
2015-09-01
Budget End
2016-05-31
Support Year
1
Fiscal Year
2015
Total Cost
$170,308
Indirect Cost
$12,571
Name
Vanderbilt University Medical Center
Department
Neurology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Jefferson, Angela L; Gifford, Katherine A; Acosta, Lealani Mae Y et al. (2016) The Vanderbilt Memory & Aging Project: Study Design and Baseline Cohort Overview. J Alzheimers Dis 52:539-59
Hohman, Timothy J; McLaren, Donald G; Mormino, Elizabeth C et al. (2016) Asymptomatic Alzheimer disease: Defining resilience. Neurology 87:2443-2450
Gifford, Katherine A; Liu, Dandan; Romano 3rd, Raymond et al. (2015) Development of a subjective cognitive decline questionnaire using item response theory: a pilot study. Alzheimers Dement (Amst) 1:429-439
Gifford, Katherine A; Liu, Dandan; Hohman, Timothy J et al. (2015) A Mutual Self- and Informant-Report of Cognitive Complaint Correlates with Neuropathological Outcomes in Mild Cognitive Impairment. PLoS One 10:e0141831
Gifford, Katherine A; Phillips, Jeffrey S; Samuels, Lauren R et al. (2015) Associations between Verbal Learning Slope and Neuroimaging Markers across the Cognitive Aging Spectrum. J Int Neuropsychol Soc 21:455-67