This K23 proposal combines focused coursework and training, a thoughtful research plan and an expert mentoring team and is designed to foster the development of Kerri Thom, MD, MS into a successful, independent investigator in the study of emerging infections and antibiotic resistance. Dr. Thom proposes to study the hospital epidemiology of Acinetobacter baumannii. This organism has emerged as an important cause of nosocomial infections due to a rising incidence, associated morbidity and mortality and the rapid development of multidrug resistance.
In Aim 1, Dr. Thom will identify Acinetobacter colonization among a large, existing cohort and will use molecular typing to quantify the amount of patient-to-patient transmission in the endemic setting.
Aim 3 will also utilize this cohort to examine the association between environmental contamination and subsequent nosocomial transmission.
In Aim 2, Dr. Thom will prospectively identify a cohort of patients infected with Acinetobacter to determine the rate of contamination of the surrounding environment and to identify heavily contaminated sites. This research will lead to an improved understanding of the hospital epidemiology of Acinetobacter, including the modes of transmission and the role of the environment in nosocomial spread, which will be essential in the development of cost-effective interventions aimed at decreasing transmission. This K23 award will provide Dr. Thom with the opportunities for specific training in molecular epidemiology, antimicrobial resistance mechanisms and research informatics which will be essential to the success of this proposal and to her future success in patient-oriented research in emerging pathogens and antimicrobial resistance. To help achieve these goals, she has assembled a mentoring team with a wealth of experience: Drs. Harris (emerging pathogens/antibiotic resistance, research informatics), Stine (molecular epidemiology, bioinformatics), Roghmann (emerging pathogens/antibiotic resistance, molecular epidemiology), Magder (biostatistics), Bonomo (antibiotic resistance mechanisms), and Srinivasan (Outbreak investigation of Acinetobacter). The support of this K23 award will provide the experience and training needed to compete for R01 NIH grant funding and will serve as a foundation for a career as an independent investigator and a leader of emerging pathogens and antibiotic resistance.

Public Health Relevance

Acinetobacter is an important cause of nosocomial infections and is associated with significant morbidity and mortality. Yet our knowledge about this organism is far less developed then that for other nosocomial pathogens, such as MRSA. Much of what we do know comes from outbreak investigations and knowledge of the modes of transmission and the role of environmental contamination in the endemic setting is lacking.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23AI082450-04
Application #
8510555
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Korpela, Jukka K
Project Start
2010-09-17
Project End
2015-08-31
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
4
Fiscal Year
2013
Total Cost
$134,730
Indirect Cost
$9,980
Name
University of Maryland Baltimore
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
188435911
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Johnson, J Kristie; Wilson, Lucy E; Zhao, Licheng et al. (2014) Point prevalence of Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae in Maryland. Infect Control Hosp Epidemiol 35:443-5
Rock, Clare; Thom, Kerri A; Masnick, Max et al. (2014) Frequency of Klebsiella pneumoniae carbapenemase (KPC)-producing and non-KPC-producing Klebsiella species contamination of healthcare workers and the environment. Infect Control Hosp Epidemiol 35:426-9
Thom, Kerri A; Li, Shanshan; Custer, Melissa et al. (2014) Successful implementation of a unit-based quality nurse to reduce central line-associated bloodstream infections. Am J Infect Control 42:139-43
Thom, Kerri A; Standiford, Harold C; Johnson, J Kristie et al. (2014) Effectiveness of an antimicrobial polymer to decrease contamination of environmental surfaces in the clinical setting. Infect Control Hosp Epidemiol 35:1060-2
Pineles, Lisa L; Morgan, Daniel J; Limper, Heather M et al. (2014) Accuracy of a radiofrequency identification (RFID) badge system to monitor hand hygiene behavior during routine clinical activities. Am J Infect Control 42:144-7
Boutin, Mallory A; Thom, Kerri A; Zhan, Min et al. (2014) A randomized crossover trial to decrease bacterial contamination on hospital scrubs. Infect Control Hosp Epidemiol 35:1411-3
Hess, Aaron S; Kleinberg, Michael; Sorkin, John D et al. (2014) Prior colonization is associated with increased risk of antibiotic-resistant Gram-negative bacteremia in cancer patients. Diagn Microbiol Infect Dis 79:73-6
Barnes, Sean L; Morgan, Daniel J; Harris, Anthony D et al. (2014) Preventing the transmission of multidrug-resistant organisms: modeling the relative importance of hand hygiene and environmental cleaning interventions. Infect Control Hosp Epidemiol 35:1156-62
Rock, Clare; Harris, Anthony D; Reich, Nicholas G et al. (2013) Is hand hygiene before putting on nonsterile gloves in the intensive care unit a waste of health care worker time?--a randomized controlled trial. Am J Infect Control 41:994-6
Ajao, Adebola O; Johnson, J Kristie; Harris, Anthony D et al. (2013) Risk of acquiring extended-spectrum ?-lactamase-producing Klebsiella species and Escherichia coli from prior room occupants in the intensive care unit. Infect Control Hosp Epidemiol 34:453-8

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