The candidate, Laura Carbone M.D., is a new investigator in the field of metabolic bone diseases. Immediate goals include acquiring expertise in study design. This will be provided on a ongoing basis by the co-mentors Dr. Genaro Palmieri, a well known expert in metabolic bone disease, and Dr. William B. Applegate, an expert in large multi-center clinical trials. Long term goals include obtaining the skills necessary to do clinical trials in metabolic bone diseases. This will be provided at this center by weekly classes in statistics and epidemiology, seminars in nutrition and osteoporosis and a program leading to a master of science degree in epidemiology. The specific research plan is detailed below: Racial differences in bone metabolism, bone mineral density and fracture rates have been reported between Caucasians and African Americans with Caucasians generally having increased biochemical markers of bone metabolism, decreased bone mineral density and higher fracture rats than African Americans. More recent data, however, suggests that the incidence of osteoporosis and osteoporotic fractures may be increasing in African Americans. Environmental factors, specifically salt intake, have been shown to influence bone metabolism in Caucasians, but have not been studied in African Americans, despite the fact that the African American diet may be high in sodium. This study proposes to examine the effects of sodium load and then a sodium restriction diet of calciotropic hormones and biochemical markers of bone metabolism in African American and Caucasian women.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23AR002042-03
Application #
6171349
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Mcgowan, Joan A
Project Start
1998-09-01
Project End
2003-08-31
Budget Start
2000-09-01
Budget End
2001-08-31
Support Year
3
Fiscal Year
2000
Total Cost
$131,480
Indirect Cost
Name
University of Tennessee Health Science Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
941884009
City
Memphis
State
TN
Country
United States
Zip Code
38163
Carbone, Laura D; Barrow, Karen D; Bush, Andrew J et al. (2005) Effects of a low sodium diet on bone metabolism. J Bone Miner Metab 23:506-13
Carbone, Laura D; Tylavsky, Frances A; Cauley, Jane A et al. (2003) Association between bone mineral density and the use of nonsteroidal anti-inflammatory drugs and aspirin: impact of cyclooxygenase selectivity. J Bone Miner Res 18:1795-802
Carbone, Laura D; Bush, Andrew J; Barrow, Karen D et al. (2003) The relationship of sodium intake to calcium and sodium excretion and bone mineral density of the hip in postmenopausal African-American and Caucasian women. J Bone Miner Metab 21:415-20