Although I have been successful as a spine surgeon in an academic environment, building a respected clinical practice and completing spine biomechanics research for competitively funded projects, I realize that clinical research most directly addresses my motivation for choosing an academic career, and that high-quality clinical research is complex, requiring a long-term commitment and specialized skills. I am in an excellent environment to develop these skills, with supportive colleagues and a supportive chairman. I have developed a five-year training schedule, with the first three years devoted to obtaining an MPH degree. A team of three outstanding individuals has committed to working with me for the next five years and guiding my career development. My immediate goal is to gain practical clinical research experience by conducting a five-year prospective study with this team of experienced and highly respected researchers. My long-term career goals are to help identify spine patient populations more concretely, measure end-results of spinal disorders in general, and define outcomes for treated and untreated back pain and whiplash injuries in particular. Research Project: The use of surgery for back pain is rapidly growing; data on its safety and outcomes are sorely needed. We propose a prospective cohort study to measure the frequency of complications in lumbar fusion surgery, variation in rates of specific serious complications with different types of lumbar fusion, clinical and functional consequences for specific types of complications, and patient or treatment characteristics that predict particularly severe complications. Over a two-year interval, we propose to enroll 1000 patients choosing fusion surgery for treatment of disc degeneration, spondylolisthesis, spinal stenosis, and adult degenerative scoliosis. We will follow these patients for two years, measure predictor patient and treatment characteristics, and measure consequences with clinical and functional outcomes. Accumulating data will be stored in an existing central database. The analysis will use appropriate univariate and multivariate techniques to address the study questions. This study will provide data on the relative benefits and risks of lumbar fusion surgery in treating back pain.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
1K23AR048979-01
Application #
6533245
Study Section
Special Emphasis Panel (ZAR1-TAS-B (M1))
Program Officer
Panagis, James S
Project Start
2002-09-30
Project End
2007-06-30
Budget Start
2002-09-30
Budget End
2003-06-30
Support Year
1
Fiscal Year
2002
Total Cost
$125,253
Indirect Cost
Name
University of Washington
Department
Orthopedics
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Lee, Michael J; Cizik, Amy M; Hamilton, Deven et al. (2014) Predicting medical complications after spine surgery: a validated model using a prospective surgical registry. Spine J 14:291-9
Mirza, Sohail K; Martin, Brook I; Goodkin, Robert et al. (2014) Developing a toolkit for comparing safety in spine surgery. Instr Course Lect 63:271-86
Manoso, Mark W; Cizik, Amy M; Bransford, Richard J et al. (2014) Medicaid status is associated with higher surgical site infection rates after spine surgery. Spine (Phila Pa 1976) 39:1707-13
Mirza, Sohail K; Deyo, Richard A; Heagerty, Patrick J et al. (2013) One-year outcomes of surgical versus nonsurgical treatments for discogenic back pain: a community-based prospective cohort study. Spine J 13:1421-33
Lee, Michael J; Konodi, Mark A; Cizik, Amy M et al. (2013) Risk factors for medical complication after cervical spine surgery: a multivariate analysis of 582 patients. Spine (Phila Pa 1976) 38:223-8
Hacquebord, Jacques; Cizik, Amy M; Malempati, Sree Harsha et al. (2013) Medicaid status is associated with higher complication rates after spine surgery. Spine (Phila Pa 1976) 38:1393-400
Karandikar, Mahesh; Mirza, Sohail K; Song, Kit et al. (2012) Complex pediatric cervical spine surgery using smaller nonspinal screws and plates and intraoperative computed tomography. J Neurosurg Pediatr 9:594-601
Baker, Geoff A; Cizik, Amy M; Bransford, Richard J et al. (2012) Risk factors for unintended durotomy during spine surgery: a multivariate analysis. Spine J 12:121-6
Lee, Michael J; Konodi, Mark A; Cizik, Amy M et al. (2012) Risk factors for medical complication after spine surgery: a multivariate analysis of 1,591 patients. Spine J 12:197-206
Lee, Michael J; Hacquebord, Jacques; Varshney, Anuj et al. (2011) Risk factors for medical complication after lumbar spine surgery: a multivariate analysis of 767 patients. Spine (Phila Pa 1976) 36:1801-6

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