Guilherme Godoy, M.D. is a Urologic Oncology fellow in the Scott Department of Urology at Baylor College of Medicine (BCM). His career has been research-oriented and his goal is to become an expert and independent investigator in the field of urological cancers, with specific focus in bladder cancer. The proposed research study includes the development of a new strategy for prevention and management of non-invasive bladder cancer using oral tamoxifen. This strategy has the potential for reduction in the cost and invasiveness of management and surveillance protocols. Dr. Godoy is enrolled in the Clinical Scientist Training Program at BCM, pursuing his Ph.D. degree in Clinical Investigation. He will receive extensive training in grant writing, research presentation, clinical trial design and management, biostatistics, and ethics in the conduct of research. BCM, as an integral part of the world-renowned Texas Medical Center, provides the ideal environment to support his training and research needs. Dr. Godoy is mentored by Seth P. Lerner, MD, FACS, Professor of Urology and Beth and Dave Swalm Chair in Urologic Oncology at the Scott Department of Urology, BCM. Dr. Lerner is a recognized leader in the field of bladder cancer, with a successful mentoring record and a solid experience in clinical trial leadership. Dr. Godoy is further supported by an advisory committee, comprising expert leaders in all areas of research related to his current project, ensuring excellence of his work. Dr. Godoy's research project is focused on investigating the role of tamoxifen in the chemoprevention of non- invasive bladder cancer recurrence. The hypotheses are that oral Tamoxifen treatment (1) is able to reduce the size or eliminate low/intermediate-risk non-muscle invasive bladder cancer tumors, and (2) show a positive correlation between the magnitude of the clinical response to the therapy with pretreatment expression levels of estrogen receptor (especially estrogen receptor ? and its splice variants) in the tumor and normal tissues. It is expected that (3) therapy will be well tolerated and also hypothesized that (4) response to treatment will be associated with changes in a previously identified bladder cancer metabolomic signature. The study of an oral drug in the treatment of non-invasive bladder cancer has the potential not only to improve oncological outcomes, but also to introduce a new paradigm in the management of bladder cancer.

Public Health Relevance

Non-invasive bladder cancer is a challenging condition to treat because of frequent recurrences, leading to numerous invasive [and costly] procedures for detection and treatment. This study explores the utilization of an oral drug (Tamoxifen) to treat and prevent tumor recurrences. The results of the present study have the potential to improve oncological outcomes, creating a new paradigm in the management of bladder cancer, potentially reducing the burden, costs, and the invasiveness of current treatment and follow-up strategies.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23CA160664-02
Application #
8721363
Study Section
Subcommittee G - Education (NCI)
Program Officer
Lim, Susan E
Project Start
2013-08-15
Project End
2017-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
2
Fiscal Year
2014
Total Cost
$142,986
Indirect Cost
$9,369
Name
Baylor College of Medicine
Department
Urology
Type
Schools of Medicine
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
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Brooks, Michael; Godoy, Guilherme; Sun, Maxine et al. (2016) External Validation of Bladder Cancer Predictive Nomograms for Recurrence, Cancer-Free Survival and Overall Survival following Radical Cystectomy. J Urol 195:283-9
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von Rundstedt, Friedrich Carl; Lerner, Seth P; Godoy, Guilherme et al. (2015) Usefulness of transurethral biopsy for staging the prostatic urethra before radical cystectomy. J Urol 193:58-63
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Goebell, Peter J; Kamat, Ashish M; Sylvester, Richard J et al. (2014) Assessing the quality of studies on the diagnostic accuracy of tumor markers. Urol Oncol 32:1051-60
Mashni, Joseph; Godoy, Guilherme; Haarer, Chadwick et al. (2014) Prospective evaluation of plasma kinetic bipolar resection of bladder cancer: comparison to monopolar resection and pathologic findings. Int Urol Nephrol 46:1699-705
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