Goal: This application requests an NIH-NIDA K23 mentored clinical researcher training grant for Dr. James Davis to conduct behavioral therapies development research. During the 5-year term of the grant, funding will be used to prepare Dr. Davis for a leadership role as a physician-researcher in the field of addiction medicine. Background: The contemporary population of smokers demonstrates treatment resistance related to high level nicotine dependence and affective comorbidities. Mindfulness training has been shown to increase attentional control and decrease negative affect and stress, effects that are particularly relevant to these sources of treatment resistance. Research: The proposed research is designed to further develop and test the new smoking intervention Mindfulness Based Smoking Cessation (MBSC) within stage-1 and stage-2 of the NIDA Behavioral Therapies Development Program. A feasibility study on mindfulness training in smokers is now complete and demonstrates promising results. Years 1 and 2 of the grant-funded period are allocated to stage-1 completion of intervention development through an intervention development study, a teacher training course, and through production of the MBSC course and training manuals. Year 3 and 4 are allocated for MBSC treatment efficacy testing through a randomized controlled trial. Year 5 is allocated to publication of results and to application for an R01 grant for research on mechanism and dissemination. Significance: Because the current US population of smokers has grown more resistant to available therapies, new techniques are needed that specifically address obstacles to treatment success such as negative affect and high nicotine dependence. Mindfulness training is a novel technique that appears to be promising in overcoming these treatment obstacles. Qualifications: Dr. Davis conducts addiction research under the mentorship of Dr. Timothy Baker at University of Wisconsin (UW) Center for Tobacco Research and Intervention. In October 2006, on completion of a research fellowship, Dr. Davis will be given a faculty appointment in the UW Department of Medicine. Proposed Training: This 5-year program is designed to develop knowledge and skills necessary for Dr. Davis to conduct high-level independent addiction research. The program incorporates mentored research with course work, ethics training, and national conferences. This grant will provide funding for Dr. Davis to develop a career as an independent addiction researcher.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23DA022471-05
Application #
8324293
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Grossman, Debra
Project Start
2008-09-28
Project End
2013-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
5
Fiscal Year
2012
Total Cost
$161,801
Indirect Cost
$11,754
Name
University of Wisconsin Madison
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Davis, James M; Goldberg, Simon B; Anderson, Maggie C et al. (2014) Randomized trial on mindfulness training for smokers targeted to a disadvantaged population. Subst Use Misuse 49:571-85
Goldberg, Simon B; Manley, Alison R; Smith, Stevens S et al. (2014) Hair cortisol as a biomarker of stress in mindfulness training for smokers. J Altern Complement Med 20:630-4
Goldberg, Simon B; Del Re, A C; Hoyt, William T et al. (2014) The secret ingredient in mindfulness interventions? A case for practice quality over quantity. J Couns Psychol 61:491-7
Davis, James M; Manley, Alison R; Goldberg, Simon B et al. (2014) Randomized trial comparing mindfulness training for smokers to a matched control. J Subst Abuse Treat 47:213-21
Goldberg, Simon B; Davis, James M; Hoyt, William T (2013) The role of therapeutic alliance in mindfulness interventions: therapeutic alliance in mindfulness training for smokers. J Clin Psychol 69:936-50