The goal of this Mentored Patient-Oriented Research Career Development Award (K23) is for Benjamin Morasco, Ph.D. to become an independent scientist studying innovative approaches for the assessment and treatment of chronic pain and comorbid substance use disorder (SLID) in patients with hepatitis C. The candidate proposes a program of research and training with the following goals: further his understanding of pain, addiction, and SLID;expand his knowledge regarding strategies to address the non-pharmacological treatment of pain and SLID;develop expertise in the psychosocial needs of patients with the hepatitis C virus (HCV);and acquire advanced research skills that will prepare him for a career as an independent investigator. Dr. Morasco will work closely with his mentors, Drs. Peter Mauser, Dennis Turk, Alan Marlatt, and Steven Dobscha throughout the course of this award to meet the above objectives. The resources at the Oregon Health &Science University and Portland VA Medical Center, combined with the expert guidance of the mentoring team, will provide the ideal opportunity for Dr. Morasco to develop expertise in the assessment and treatment of comorbid pain and SLID. As part of this K23 award, Dr. Morasco will (1) conduct a cross-sectional study examining the biopsychosocial factors that are associated with chronic pain in patients with HCV, and (2) develop and pilot test a group-based cognitive-behavioral treatment to reduce pain, improve physical and emotional functioning, and reduce substance use in patients with HCV. Results from these studies will be used to apply for R01 funding to test the newly developed intervention in a randomized controlled trial. The long-term goal of this research is to develop a better understanding of the treatment needs of HCV patients, and ultimately improve the treatment of pain and comorbid substance use in this patient population. Successful completion of the proposed studies will prepare Dr. Morasco to become an independent investigator with expertise conducting clinical research in the combined treatment of pain and SLID, particularly in patients with HCV. Relevance to Public Health: We expect that this project will contribute needed information about the factors that contribute to pain in patients with hepatitis C. If the newly developed treatment is effective, the health-related quality of life among hepatitis C patients will be improved.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Mentored Patient-Oriented Research Career Development Award (K23)
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Special Emphasis Panel (ZDA1-EXL-T (04))
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Aklin, Will
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Oregon Health and Science University
Schools of Medicine
United States
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Lovejoy, Travis I; Dobscha, Steven K; Turk, Dennis C et al. (2016) Correlates of prescription opioid therapy in Veterans with chronic pain and history of substance use disorder. J Rehabil Res Dev 53:25-36
Morasco, Benjamin J; Krebs, Erin E; Cavanagh, Renee et al. (2015) Treatment changes following aberrant urine drug test results for patients prescribed chronic opioid therapy. J Opioid Manag 11:45-51
Adams, Melissa H; Lovejoy, Travis I; Turk, Dennis C et al. (2015) Pain-related anxiety mediates the relationship between depressive symptoms and pain interference in veterans with hepatitis C. Gen Hosp Psychiatry 37:533-7
Morasco, Benjamin J; Turk, Dennis C; Nicolaidis, Christina (2015) Psychometric Properties of the Centrality of Pain Scale. J Pain 16:676-81
Morasco, Benjamin J; O?Neil, Maya E; Duckart, Jonathan P et al. (2014) Comparison of health service use among veterans with methamphetamine versus alcohol use disorders. J Addict Med 8:47-52
Morasco, Benjamin J; Lovejoy, Travis I; Turk, Dennis C et al. (2014) Biopsychosocial factors associated with pain in veterans with the hepatitis C virus. J Behav Med 37:902-11
Dobscha, Steven K; Morasco, Benjamin J; Duckart, Jonathan P et al. (2013) Correlates of prescription opioid initiation and long-term opioid use in veterans with persistent pain. Clin J Pain 29:102-8
Morasco, Benjamin J; Cavanagh, Renee; Gritzner, Susan et al. (2013) Care management practices for chronic pain in veterans prescribed high doses of opioid medications. Fam Pract 30:671-8
Morasco, Benjamin J; Turk, Dennis C; Donovan, Dennis M et al. (2013) Risk for prescription opioid misuse among patients with a history of substance use disorder. Drug Alcohol Depend 127:193-9
Weimer, Melissa B; Macey, Tara A; Nicolaidis, Christina et al. (2013) Sex differences in the medical care of VA patients with chronic non-cancer pain. Pain Med 14:1839-47

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