Dr. Bruce K. Tan is an Assistant Professor in the Department of Otolaryngology-Head and Neck Surgery at the Northwestern University Feinberg School of Medicine where his clinical practice is dedicated to rhinolology and olfactory loss. This career development award, under the mentorship of Drs. Robert P. Schleimer and Jay A. Gottfried, is focused on understanding the impact of B-cell mediated inflammation on the pathogenesis and olfactory loss associated with Chronic Sinusitis with Nasal Polyps (CRSwNP). CRSwNP is a prevalent inflammatory condition of the nose and paranasal sinuses that is a major cause of acquired olfactory loss. Currently, the inflammatory mechanisms driving this disease are poorly understood, thus limiting the classes of therapeutic agents utilized to treat this disease. We have increasing evidence and further preliminary data showing that B-cell inflammation and autoimmunity is present within some nasal polyps and may play an important role in the persistent inflammation associated with CRSwNP. The candidate is proposing two non-overlapping, but complementary, aims that seek to understand the role for B-cell mediated inflammation in olfactory loss in CRSwNP.
In Aim 1, the candidate will utilize a set of superior turbinate tissue from CRSwNP patients and normal controls to evaluate the impact of B-cell inflammation in olfactory tissue.
In Aim 2, he will establish if the autoantibodies found in CRSwNP are associated with molecular markers of pathogenicity and clinical evidence for persistent inflammation and olfactory loss following surgical therapy. During this award, Dr. Tan will also acquire practical training and coursework in immunology, biostatistics and study design. This training and the data generated though the proposed aims will form the basis for the candidate's future career as an independent investigator.

Public Health Relevance

Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) is a major cause of smell loss. The mechanisms driving inflammation in this disease are poorly understood and result in limited treatments in this disease. We have recently discovered that B-cell inflammation and autoimmunity are active in the noses of patients with CRSwNP and these studies aim to assess the impact of these forms of inflammation on smell loss.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23DC012067-02
Application #
8399713
Study Section
Communication Disorders Review Committee (CDRC)
Program Officer
Sklare, Dan
Project Start
2011-12-15
Project End
2016-11-30
Budget Start
2012-12-01
Budget End
2013-11-30
Support Year
2
Fiscal Year
2013
Total Cost
$228,802
Indirect Cost
$16,817
Name
Northwestern University at Chicago
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Ference, Elisabeth H; Suh, Jeffrey D; Tan, Bruce K et al. (2018) How often is sinus surgery performed for chronic rhinosinusitis with versus without nasal polyps? Am J Rhinol Allergy 32:34-39
Lidder, Alcina K; Detwiller, Kara Y; Price, Caroline P E et al. (2017) Evaluating metrics of responsiveness using patient-reported outcome measures in chronic rhinosinusitis. Int Forum Allergy Rhinol 7:128-134
Van Roey, Griet A; Vanison, Christopher C; Wu, Jeffanie et al. (2017) Classical complement pathway activation in the nasal tissue of patients with chronic rhinosinusitis. J Allergy Clin Immunol 140:89-100.e2
Ghadersohi, Saied; Tan, Bruce K (2017) Contemporary Pharmacotherapy for Allergic Rhinitis and Chronic Rhinosinusitis. Otolaryngol Clin North Am 50:1135-1151
Tan, Bruce K; Klingler, Aiko I; Poposki, Julie A et al. (2017) Heterogeneous inflammatory patterns in chronic rhinosinusitis without nasal polyps in Chicago, Illinois. J Allergy Clin Immunol 139:699-703.e7
Weibman, Ava R; Huang, Julia He; Stevens, Whitney W et al. (2017) A prospective analysis evaluating tissue biopsy location and its clinical relevance in chronic rhinosinusitis with nasal polyps. Int Forum Allergy Rhinol 7:1058-1064
Min, Jin-Young; Ocampo, Christopher J; Stevens, Whitney W et al. (2017) Proton pump inhibitors decrease eotaxin-3/CCL26 expression in patients with chronic rhinosinusitis with nasal polyps: Possible role of the nongastric H,K-ATPase. J Allergy Clin Immunol 139:130-141.e11
Min, Jin-Young; Nayak, Jayakar V; Hulse, Kathryn E et al. (2017) Evidence for altered levels of IgD in the nasal airway mucosa of patients with chronic rhinosinusitis. J Allergy Clin Immunol 140:1562-1571.e5
Lavin, Jennifer; Min, Jin-Young; Lidder, Alcina K et al. (2017) Superior turbinate eosinophilia correlates with olfactory deficit in chronic rhinosinusitis patients. Laryngoscope 127:2210-2218
Thompson, Christopher F; Price, Caroline P E; Huang, Julia He et al. (2016) A pilot study of symptom profiles from a polyp vs an eosinophilic-based classification of chronic rhinosinusitis. Int Forum Allergy Rhinol 6:500-7

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