Dr. Bruce K. Tan is an Assistant Professor in the Department of Otolaryngology-Head and Neck Surgery at the Northwestern University Feinberg School of Medicine where his clinical practice is dedicated to rhinolology and olfactory loss. This career development award, under the mentorship of Drs. Robert P. Schleimer and Jay A. Gottfried, is focused on understanding the impact of B-cell mediated inflammation on the pathogenesis and olfactory loss associated with Chronic Sinusitis with Nasal Polyps (CRSwNP). CRSwNP is a prevalent inflammatory condition of the nose and paranasal sinuses that is a major cause of acquired olfactory loss. Currently, the inflammatory mechanisms driving this disease are poorly understood, thus limiting the classes of therapeutic agents utilized to treat this disease. We have increasing evidence and further preliminary data showing that B-cell inflammation and autoimmunity is present within some nasal polyps and may play an important role in the persistent inflammation associated with CRSwNP. The candidate is proposing two non-overlapping, but complementary, aims that seek to understand the role for B-cell mediated inflammation in olfactory loss in CRSwNP.
In Aim 1, the candidate will utilize a set of superior turbinate tissue from CRSwNP patients and normal controls to evaluate the impact of B-cell inflammation in olfactory tissue.
In Aim 2, he will establish if the autoantibodies found in CRSwNP are associated with molecular markers of pathogenicity and clinical evidence for persistent inflammation and olfactory loss following surgical therapy. During this award, Dr. Tan will also acquire practical training and coursework in immunology, biostatistics and study design. This training and the data generated though the proposed aims will form the basis for the candidate's future career as an independent investigator.

Public Health Relevance

Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) is a major cause of smell loss. The mechanisms driving inflammation in this disease are poorly understood and result in limited treatments in this disease. We have recently discovered that B-cell inflammation and autoimmunity are active in the noses of patients with CRSwNP and these studies aim to assess the impact of these forms of inflammation on smell loss.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23DC012067-03
Application #
8586309
Study Section
Communication Disorders Review Committee (CDRC)
Program Officer
Sklare, Dan
Project Start
2011-12-15
Project End
2016-11-30
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
3
Fiscal Year
2014
Total Cost
$228,811
Indirect Cost
$16,826
Name
Northwestern University at Chicago
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Daramola, Opeyemi O; Lidder, Alcina K; Ramli, Ramiza et al. (2015) Patient knowledge and perception of computed tomography scan in the management of chronic rhinosinusitis symptoms. Laryngoscope 125:791-5
Smith, Stephanie S; Ference, Elisabeth H; Evans, Charlesnika T et al. (2015) The prevalence of bacterial infection in acute rhinosinusitis: a Systematic review and meta-analysis. Laryngoscope 125:57-69
Mahdavinia, Mahboobeh; Suh, Lydia A; Carter, Roderick G et al. (2015) Increased noneosinophilic nasal polyps in chronic rhinosinusitis in US second-generation Asians suggest genetic regulation of eosinophilia. J Allergy Clin Immunol 135:576-9
Lam, Kent; Hirsch, Annemarie G; Tan, Bruce K (2014) The association of premorbid diseases with chronic rhinosinusitis with and without polyps. Curr Opin Otolaryngol Head Neck Surg 22:231-41
Mahdavinia, Mahboobeh; Carter, Roderick G; Ocampo, Christopher J et al. (2014) Basophils are elevated in nasal polyps of patients with chronic rhinosinusitis without aspirin sensitivity. J Allergy Clin Immunol 133:1759-63
Seshadri, Sudarshan; Rosati, Mariel; Lin, David C et al. (2013) Regional differences in the expression of innate host defense molecules in sinonasal mucosa. J Allergy Clin Immunol 132:1227-1230.e5
Tan, Bruce K; Lu, Guanning; Kwasny, Mary J et al. (2013) Effect of symptom-based risk stratification on the costs of managing patients with chronic rhinosinusitis symptoms. Int Forum Allergy Rhinol 3:933-40
Jeffe, Jill S; Seshadri, Sudarshan; Hamill, Kevin J et al. (2013) A role for anti-BP180 autoantibodies in chronic rhinosinusitis. Laryngoscope 123:2104-11
Hsueh, Wayne D; Conley, David B; Kim, Haena et al. (2013) Identifying clinical symptoms for improving the symptomatic diagnosis of chronic rhinosinusitis. Int Forum Allergy Rhinol 3:307-14
Smith, Stephanie Shintani; Evans, Charlesnika T; Tan, Bruce K et al. (2013) National burden of antibiotic use for adult rhinosinusitis. J Allergy Clin Immunol 132:1230-2

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