Candidate: The candidate is committed to a career in academic dentistry, with a focus on patient-oriented research. This award will enable the candidate to achieve his immediate career objective, which is to gain additional training and experience in patient-oriented research. This will in turn enable him to achieve his long-term career goal, which is to become an independent funded investigator in patient-oriented research. Mentors: The primary mentor will be Dr. Douglas Peterson who has extensive expertise and experience in patient-oriented research related to oral mucositis. The co-mentor will be Dr. Carol Pilbeam who conducts NIH-funded basic science research related to the cyclooxygenase (COX) pathway. This complementary combination of clinical and basic science expertise will ensure a comprehensive training program. Environment: A well-established research program in the proposed research area is in place. An NIH-funded GCRC provides a comprehensive range of supportive services for clinical research. Strong evidence of institutional commitment to the candidate's career development is documented in the application. Career Development Plan: The didactic component will include a range of course-work in areas relevant to patient-oriented research. The clinical component will include experience in at least three separate clinical research studies. The laboratory component will include hands-on experience in RT-PCR and ELISA. Research Plan: Most patients treated with radiation therapy for head & neck cancer develop ulcerative oral lesions called oral mucositis (OM). OM is painful and compromises nutrition & quality of life. OM causes interruptions in radiation therapy, thus adversely affecting cancer therapy outcomes. Hypothesis: COX-2 contributes to mucosal injury in radiation-induced OM.
Specific Aims : 1. To determine effects of a selective COX-2 inhibitor on clinical mucosal injury in radiation-induced OM. 2. To examine mechanisms leading to mucosal injury in radiation-induced OM and effects of the selective COX-2 inhibitor on these mechanisms.
|Krause, Colleen E; Otieno, Brunah A; Bishop, Gregory W et al. (2015) Ultrasensitive microfluidic array for serum pro-inflammatory cytokines and C-reactive protein to assess oral mucositis risk in cancer patients. Anal Bioanal Chem 407:7239-43|
|Lalla, Rajesh V; Choquette, Linda E; Curley, Kathleen F et al. (2014) Randomized double-blind placebo-controlled trial of celecoxib for oral mucositis in patients receiving radiation therapy for head and neck cancer. Oral Oncol 50:1098-103|
|D'Amato-Palumbo, Sandra; Kaplan, Andre A; Feinn, Richard S et al. (2013) Retrospective study of microorganisms associated with vascular access infections in hemodialysis patients. Oral Surg Oral Med Oral Pathol Oral Radiol 115:56-61|
|Lalla, Rajesh V; Choquette, Linda E; Feinn, Richard S et al. (2012) Multivitamin therapy for recurrent aphthous stomatitis: a randomized, double-masked, placebo-controlled trial. J Am Dent Assoc 143:370-6|
|Huling, Laura B; Baccaglini, Lorena; Choquette, Linda et al. (2012) Effect of stressful life events on the onset and duration of recurrent aphthous stomatitis. J Oral Pathol Med 41:149-52|
|Gatehouse, Christopher S; Tennen, Howard A; Feinn, Richard S et al. (2012) Association between interactive voice response adherence and subject retention in a randomized controlled trial. Contemp Clin Trials 33:589-92|
|Peterson, Douglas E; Bensadoun, Rene-Jean; Lalla, Rajesh V et al. (2011) Supportive care treatment guidelines: value, limitations, and opportunities. Semin Oncol 38:367-73|
|Baccaglini, L; Lalla, R V; Bruce, A J et al. (2011) Urban legends: recurrent aphthous stomatitis. Oral Dis 17:755-70|
|Lalla, Rajesh V; Bensadoun, Rene-Jean (2011) Miconazole mucoadhesive tablet for oropharyngeal candidiasis. Expert Rev Anti Infect Ther 9:13-7|
|Peterson, Douglas E; Lalla, Rajesh V (2010) Oral mucositis: the new paradigms. Curr Opin Oncol 22:318-22|
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