The Mentored Patient-Oriented Research Career Development Award (K23) will provide protected time, at 75%, for the principal investigator to develop independent research expertise in the design, conduct, and analysis of patient- oriented research in dental medicine. The proposed career development plan basis on the candidate's interests and previous training and experience in periodontology and systemic diseases and clinical investigations. The five-year plan is designed to lead to the candidate receiving the degree of Master of Arts, in the area of Clinical Investigations, from the Boston University School of Medicine and to provide her with experience of conducting independent research program in the field of clinical research. The career development plan proposes an initial period of didactic work, together with a supervised research experience involving a prospective, interventional clinical research study of diabetes and periodontal infections, in the proposed five-year award period. The formal training in clinical investigation and the supervised research program will provide the candidate with the preparation needed to carry out her proposed research project involving a periodontal health intervention study in a cohort of patients with diabetes being followed at Boston University Medical Center and BostonNet Health Centers. The candidate will be mentored by experienced investigators who have a successful track record of guiding the work of research trainees. This K23 program will take a full advantage of active research collaborations, and provide the candidate with a broad exposure to patient-oriented research. In turn, these existing patient-oriented research projects, funded by the NIH, and corporate and foundation sponsors, will benefit by the ability to involve the candidate in these programs. The principal investigator will have the opportunity to build on existing research projects in the area of periodontal health determinants and systemic disease and quality of life outcomes, with a special focus on the study of clinical interventional study of the relationship of periodontal diseases and diabetes and especially the impact of periodontal treatment on the control of the diabetic complications.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23DE018917-06
Application #
8266271
Study Section
NIDCR Special Grants Review Committee (DSR)
Program Officer
King, Lynn M
Project Start
2008-06-01
Project End
2013-11-30
Budget Start
2012-06-01
Budget End
2013-11-30
Support Year
6
Fiscal Year
2012
Total Cost
$129,465
Indirect Cost
$9,590
Name
Forsyth Institute
Department
Type
DUNS #
062190616
City
Cambridge
State
MA
Country
United States
Zip Code
02142
Herrera, Bruno S; Hasturk, Hatice; Kantarci, Alpdogan et al. (2015) Impact of resolvin E1 on murine neutrophil phagocytosis in type 2 diabetes. Infect Immun 83:792-801
Hasturk, Hatice; Abdallah, Rima; Kantarci, Alpdogan et al. (2015) Resolvin E1 (RvE1) Attenuates Atherosclerotic Plaque Formation in Diet and Inflammation-Induced Atherogenesis. Arterioscler Thromb Vasc Biol 35:1123-33
Hasturk, Hatice; Kantarci, Alpdogan (2015) Activation and resolution of periodontal inflammation and its systemic impact. Periodontol 2000 69:255-73
Kantarci, Alpdogan; Hasturk, Hatice; Van Dyke, Thomas E (2015) Animal models for periodontal regeneration and peri-implant responses. Periodontol 2000 68:66-82
Van Dyke, T E; Hasturk, H; Kantarci, A et al. (2015) Proresolving nanomedicines activate bone regeneration in periodontitis. J Dent Res 94:148-56
Elabdeen, H R Z; Mustafa, M; Hasturk, H et al. (2015) Subgingival microbial profiles of Sudanese patients with aggressive periodontitis. J Periodontal Res 50:674-82
Ayilavarapu, Srinivas; Kantarci, Alpdogan; Hasturk, Hatice et al. (2014) IPLA2 mRNA expression by human neutrophils in type 2 diabetes and chronic periodontitis. J Int Acad Periodontol 16:121-6
Cekici, Ali; Kantarci, Alpdogan; Hasturk, Hatice et al. (2014) Inflammatory and immune pathways in the pathogenesis of periodontal disease. Periodontol 2000 64:57-80
Martin, Camilia R; Zaman, Munir M; Gilkey, Calvin et al. (2014) Resolvin D1 and lipoxin A4 improve alveolarization and normalize septal wall thickness in a neonatal murine model of hyperoxia-induced lung injury. PLoS One 9:e98773
Zenobia, Camille; Hasturk, Hatice; Nguyen, Daniel et al. (2014) Porphyromonas gingivalis lipid A phosphatase activity is critical for colonization and increasing the commensal load in the rabbit ligature model. Infect Immun 82:650-9

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