The overall objectives of the proposed work are: (1) to prepare the principal investigator for an independent career in patient-oriented clinical research, specifically in inflammatory bowel disease (IBD) and (2) to develop an effective tool to help patients with Crohn's disease make difficult healthcare decisions. The principal investigator spent a year as the IBD fellow at the Massachusetts General Hospital studying patient care and clinical research techniques for patients with IBD. Dr. Siegel is now the Director of the Inflammatory Bowel Disease Center at the Dartmouth-Hitchcock Medical Center, and has been focused on research involving decision making for IBD treatments. The candidate's immediate goals are to obtain formal training towards a Master of Science Degree in clinical/health services research, continue involvement in research regarding patient decision making in IBD, and to build the IBD Center at the Dartmouth-Hitchcock Medical Center. Long-term career goals include becoming a leader in clinical research in IBD, applying for further funding to study patient decision making (RO1 or equivalent), and developing the Dartmouth-Hitchcock IBD Center as the premier site studying patient decision making in IBD. Dartmouth Medical School's Center for Evaluative Clinical Sciences is one of the few institutions in the world studying shared decision making. The environment at Dartmouth is ideal for Dr. Siegel to study and learn with world's experts and bring the concepts of shared decision making to the field of IBD. The proposed project is to develop a decision aid for patients with moderately active Crohn's disease. The hypothesis is that a properly developed decision aid will allow patients to make more informed and higher quality medical decisions. Systematic surveys will be performed to ascertain the needs of patients and physicians, and through a balanced presentation of the medical literature, a decision aid will be developed and pilot tested. Relevance - As powerful new treatments for Crohn's disease are developed, we need to properly educate our patients regarding the benefit and harms of therapy. A decision aid will provide patients with clear and accurate information and allow them to choose treatments that match with their personal values.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Mentored Patient-Oriented Research Career Development Award (K23)
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Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
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Podskalny, Judith M,
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Dartmouth College
Internal Medicine/Medicine
Schools of Medicine
United States
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Dulai, Parambir S; Siegel, Corey A; Dubinsky, Marla C (2013) Balancing and communicating the risks and benefits of biologics in pediatric inflammatory bowel disease. Inflamm Bowel Dis 19:2927-36
Parker, Siddhartha; Chambers White, Laura; Spangler, Chad et al. (2013) A quality improvement project significantly increased the vaccination rate for immunosuppressed patients with IBD. Inflamm Bowel Dis 19:1809-14
Mason, Mysha; Siegel, Corey A (2013) Do inflammatory bowel disease therapies cause cancer? Inflamm Bowel Dis 19:1306-21
Siegel, Corey A (2012) Shared decision making in inflammatory bowel disease: helping patients understand the tradeoffs between treatment options. Gut 61:459-65
Siegel, Corey A; Finlayson, Samuel R G; Sands, Bruce E et al. (2012) Adverse events do not outweigh benefits of combination therapy for Crohn's disease in a decision analytic model. Clin Gastroenterol Hepatol 10:46-51
Siegel, Corey A; Siegel, Lori S; Hyams, Jeffrey S et al. (2011) Real-time tool to display the predicted disease course and treatment response for children with Crohn's disease. Inflamm Bowel Dis 17:30-8
Siegel, C A (2011) Review article: explaining risks of inflammatory bowel disease therapy to patients. Aliment Pharmacol Ther 33:23-32
Wilcox, Allison R; Dragnev, Maria Concepcion C; Darcey, Christopher J et al. (2010) A new tool to measure the burden of Crohn's disease and its treatment: do patient and physician perceptions match? Inflamm Bowel Dis 16:645-50
Siegel, Corey A; Melmed, Gil Y; Ullman, Thomas A (2010) Improving quality of care in IBD: a STEEEP challenge. Inflamm Bowel Dis 16:134-6
Siegel, Corey A (2010) Lost in translation: helping patients understand the risks of inflammatory bowel disease therapy. Inflamm Bowel Dis 16:2168-72

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