The long-term objectives of this application are twofold: first, to explore the role of the sympathetic nervous system in the pathophysiology of metabolic control;and second, for the applicant to acquire the skill set needed to become an independent investigator. The metabolic syndrome is associated with an increased risk of cardiovascular disease and premature death and the control of key metabolic processes such as lipolysis, glucose regulation, and energy expenditure are linked to the sympathetic nervous system. We believe sympathetic activation is the """"""""missing link"""""""" to the metabolic syndrome. In this proposal, we describe a collaborative, multidisciplinary approach designed to study the relationship of muscle sympathetic activity (MSNA) in humans to insulin sensitivity, lipolysis, and energy expenditure. This plan takes advantage of the expertise of the applicant""""""""s mentors and consultants to take a unique approach to this problem. This research plan will also serve as a tool for the development of the applicant, who is at a perfect stage in his career for the K23 program. A strong, experienced, well funded mentorship team is in place that will ensure that the applicant will develop into an independent clinical researcher positioned to obtain long-term independent funding. A comprehensive career development plan has been developed by the applicant and his mentors that takes advantage of the commitment of the applicant's department and institution to developing young clinician scientists and the research environment at Mayo Clinic, including its CTSA. Relevance: This project has immediate and important public health relevance. The metabolic syndrome is a major contributor to morbidity and mortality world-wide and little is known about its basic causes. By understanding the link between the autonomic nervous system and metabolic dysfuntion, we may be able to better prevent and treat this important disease.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
Application #
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Hyde, James F
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Mayo Clinic, Rochester
United States
Zip Code
Al-Khateeb, Abdulrahman A; Limberg, Jacqueline K; Barnes, Jill N et al. (2017) Acute cyclooxygenase inhibition and baroreflex sensitivity in lean and obese adults. Clin Auton Res 27:17-23
Goodman, Brent P; Claassen, Daniel; Mehdirad, Ali (2017) Adjusting droxidopa for neurogenic orthostatic hypotension in a patient with Parkinson disease. Clin Auton Res 27:17-19
Karon, Brad S; Donato, Leslie J; Larsen, Chelsie M et al. (2017) Accuracy of Capillary and Arterial Whole Blood Glucose Measurements Using a Glucose Meter in Patients under General Anesthesia in the Operating Room. Anesthesiology 127:466-474
Harvey, Ronee E; Hart, Emma C; Charkoudian, Nisha et al. (2015) Oral Contraceptive Use, Muscle Sympathetic Nerve Activity, and Systemic Hemodynamics in Young Women. Hypertension 66:590-7
Curry, Timothy B; Hines, Casey N; Barnes, Jill N et al. (2014) Relationship of muscle sympathetic nerve activity to insulin sensitivity. Clin Auton Res 24:77-85
Taylor, Jennifer L; Curry, Timothy B; Matzek, Luke J et al. (2014) Acute effects of a mixed meal on arterial stiffness and central hemodynamics in healthy adults. Am J Hypertens 27:331-7
Casey, Darren P; Curry, Timothy B; Charkoudian, Nisha et al. (2013) The effects of acute beta-adrenergic blockade on aortic wave reflection in postmenopausal women. Am J Hypertens 26:503-10
Pierce, Gary L; Casey, Darren P; Fiedorowicz, Jess G et al. (2013) Aortic pulse wave velocity and reflecting distance estimation from peripheral waveforms in humans: detection of age- and exercise training-related differences. Am J Physiol Heart Circ Physiol 305:H135-42
Curry, Timothy B; Somaraju, Madhuri; Hines, Casey N et al. (2013) Sympathetic support of energy expenditure and sympathetic nervous system activity after gastric bypass surgery. Obesity (Silver Spring) 21:480-5
Casey, Darren P; Curry, Timothy B; Joyner, Michael J et al. (2012) Acute ?-adrenergic blockade increases aortic wave reflection in young men and women: differing mechanisms between sexes. Hypertension 59:145-50

Showing the most recent 10 out of 16 publications