This application is for a Mentored Patient-Oriented Research Career Development Award (K23). The candidate, Rachel D. Barnes, Ph.D., has a programmatic interest in innovative treatments for overweight and obesity within multidisciplinary teams and furthering understanding of novel weight-related variables. Dr. Barnes plans, as a junior faculty member at Yale University School of Medicine (YSM), to acquire the necessary skills to successfully obtain extramural funding and become an independent clinical researcher in the area of obesity. The training and research plan comprises the expert mentorship and collaboration of Carlos M. Grilo, Ph.D., Professor of Psychiatry at YSM, Professor of Psychology at Yale University, and Director of the Program for Obesity, Weight, and Eating Research, and Deborah Tate, Ph.D., Associate Professor with joint appointments in the Gillings School of Public Health in the Departments of Health Behavior and Health Education, and the Department of Nutrition at the University of North Carolina School of Medicine, Chapel Hill. These mentors, along with internationally recognized contributors from YSM, will assist Dr. Barnes in achieving and maximizing the training and research plans. Dr. Barnes plans to devote a minimum of 75% of her time to obtaining further knowledge and expertise in behavioral and psychological factors associated with obesity and in intervening with overweight and obesity. Her specific training development goals proposed for the K23 are to: 1) Acquire greater expertise with assessing and intervening with obesity in different settings;2) Design and conduct a randomized clinical trial;and 3) Obtain training and perform research in psychological approaches relevant to improving clinical methods for intervening for obesity. The research plan for this application is comprised of three interrelated studies designed to: 1) Validate the Food Thought Suppression Inventory (FTSI) within an overweight and obese treatment seeking sample;2) Examine the FTSI within a randomized controlled trial (RCT) for binge eating disorder;and 3) Conduct an innovative RCT treating obesity within primary care using an easily accessible and financially feasible internet treatment enhanced with motivational interviewing. Collectively, these studies will increase Dr. Barnes's knowledge of ethics and complexities of conducting clinical trials, including statistical sophistication and methodologies, and will inform the development of R01 applications. The proposed research has the potential to improve our understanding of a systems based, broad approach to treating obesity and novel weight-related constructs. The K23 will support Dr. Barnes's transition to an independent clinical-researcher in the field of obesity.

Public Health Relevance

The proposed research addresses the public health epidemic of obesity by examining an innovative web-based obesity treatment provided in primary care centers. Further, novel obesity-related variables will be examined in hopes to improve future treatments.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Mentored Patient-Oriented Research Career Development Award (K23)
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Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Podskalny, Judith M,
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Yale University
Schools of Medicine
New Haven
United States
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Barnes, Rachel D; White, Marney A; Martino, Steve et al. (2014) A randomized controlled trial comparing scalable weight loss treatments in primary care. Obesity (Silver Spring) 22:2508-16
Blomquist, Kerstin K; Roberto, Christina A; Barnes, Rachel D et al. (2014) Development and validation of the eating loss of control scale. Psychol Assess 26:77-89
Ivezaj, Valentina; Kalebjian, Roushig; Grilo, Carlos M et al. (2014) Comparing weight gain in the year prior to treatment for overweight and obese patients with and without binge eating disorder in primary care. J Psychosom Res 77:151-4
Grilo, Carlos M; Masheb, Robin M; White, Marney A et al. (2014) Treatment of binge eating disorder in racially and ethnically diverse obese patients in primary care: randomized placebo-controlled clinical trial of self-help and medication. Behav Res Ther 58:1-9
Barnes, Rachel D; Ivezaj, Valentina; Grilo, Carlos M (2014) An examination of weight bias among treatment-seeking obese patients with and without binge eating disorder. Gen Hosp Psychiatry 36:177-80
Udo, Tomoko; McKee, Sherry A; White, Marney A et al. (2014) The factor structure of the metabolic syndrome in obese individuals with binge eating disorder. J Psychosom Res 76:152-7
Udo, Tomoko; McKee, Sherry A; White, Marney A et al. (2014) Menopause and metabolic syndrome in obese individuals with binge eating disorder. Eat Behav 15:182-5
Barnes, Rachel D; Sawaoka, Takuya; White, Marney A et al. (2013) Factor structure and clinical correlates of the Food Thought Suppression Inventory within treatment seeking obese women with binge eating disorder. Eat Behav 14:35-9
Grilo, Carlos M; White, Marney A; Barnes, Rachel D et al. (2013) Psychiatric disorder co-morbidity and correlates in an ethnically diverse sample of obese patients with binge eating disorder in primary care settings. Compr Psychiatry 54:209-16
Barnes, Rachel D; Masheb, Robin M; White, Marney A et al. (2013) Examining the relationship between food thought suppression and binge eating disorder. Compr Psychiatry 54:1077-81

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