Dr. Maitreyi Mazumdar is Assistant In Neurology at Children's Hospital Boston and Instructor In Neurology at Harvard Medical School. The candidate's long-term goal is to develop an Independent research career focusing on the role of environmental contaminants in the development of neurological Injury and disease In children. Dr. Mazumdar's Interests in this field developed during her Fellowship in neurodevelopmental toxicology, when she became aware of Investigations of the effects of environmental arsenic exposure on children in Bangladesh. The proposed career development plan incorporates a multl-disclplinary program designed to provide an Intense, closely mentored, patient-oriented research experience, associated with a comprehensively structured didactic curriculum In environmental epidemiology, exposure assessment, advanced biostatistics, andriskassessment. Under the mentorship of Dr. David Christiani, Professor of Environmental Health at the Harvard School of Public Health, the candidate will investigate the effect of prenatal and eariy childhood arsenic exposure on neurodevelopment of children In Bangladesh, a country with high levels of arsenic contamination In groundwater. This research will examine epidemiological associations of arsenic exposure with measures of neurological development In infants and children, including 1) head circumference, 2) hearing impairment, 3) motor dysfunction, and 4) formal neurocognitive testing. The studies will be conducted in a cohort of 600 infants who are participating In a current study of reproductive health effects of arsenic. Additional children between the ages of 12 and 24 months wlll also be recruited neurodevelopmental assessment. The superb clinical, research, and teaching facilities of Children's Hospital Boston, Harvard Medical School, and the Harvard School of Public Health will support Dr. Mazumdar in meeting the objectives of her career development and research plans.

Public Health Relevance

Studies have linked chronic exposure to arsenic with adverse health outcomes in adults, but its effect on children is unknown. The proposed work will examine the neurodevelopmental effects of prenatal and eariy- life arsenic exposure on Infants and young children in Bangladesh, an area with extremely high groundwater arsenic concentrations. Findings from this work will directly inform ongoing environmental risk assessment.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23ES017437-04
Application #
8282814
Study Section
Special Emphasis Panel (ZES1-JAB-J (K9))
Program Officer
Shreffler, Carol K
Project Start
2009-09-01
Project End
2014-05-31
Budget Start
2012-06-01
Budget End
2013-05-31
Support Year
4
Fiscal Year
2012
Total Cost
$143,142
Indirect Cost
$10,292
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Gleason, Kelsey M; Valeri, Linda; Shankar, A H et al. (2016) Stunting is associated with blood lead concentration among Bangladeshi children aged 2-3 years. Environ Health 15:103
Rodrigues, Ema G; Bellinger, David C; Valeri, Linda et al. (2016) Neurodevelopmental outcomes among 2- to 3-year-old children in Bangladesh with elevated blood lead and exposure to arsenic and manganese in drinking water. Environ Health 15:44
Mazumdar, Maitreyi; Valeri, Linda; Rodrigues, Ema G et al. (2015) Polymorphisms in maternal folate pathway genes interact with arsenic in drinking water to influence risk of myelomeningocele. Birth Defects Res A Clin Mol Teratol 103:754-62
Mazumdar, Maitreyi; Ibne Hasan, Md Omar Sharif; Hamid, Rezina et al. (2015) Arsenic is associated with reduced effect of folic acid in myelomeningocele prevention: a case control study in Bangladesh. Environ Health 14:34
Bobb, Jennifer F; Valeri, Linda; Claus Henn, Birgit et al. (2015) Bayesian kernel machine regression for estimating the health effects of multi-pollutant mixtures. Biostatistics 16:493-508
Mazumdar, Maitreyi; Christiani, David C; Biswas, Subrata K et al. (2015) Elevated sweat chloride levels due to arsenic toxicity. N Engl J Med 372:582-4
Kile, Molly L; Rodrigues, Ema G; Mazumdar, Maitreyi et al. (2014) A prospective cohort study of the association between drinking water arsenic exposure and self-reported maternal health symptoms during pregnancy in Bangladesh. Environ Health 13:29
Gleason, Kelsey; Shine, James P; Shobnam, Nadia et al. (2014) Contaminated turmeric is a potential source of lead exposure for children in rural Bangladesh. J Environ Public Health 2014:730636
Bernson-Leung, Miya E; Mazumdar, Maitreyi (2014) Journal club: pretreatment EEG in childhood absence epilepsy. Neurology 82:e158-60
Mazumdar, Maitreyi; Xia, Weiming; Hofmann, Oliver et al. (2012) Prenatal lead levels, plasma amyloid β levels, and gene expression in young adulthood. Environ Health Perspect 120:702-7

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