(Candidate's Abstract) The overall goal of this application is to develop research skills for independent patient-oriented (clinical and fundamental) investigations through (a) didactic courses, (b) special studies and (c) intensive supervised research. The candidate for this K23 award has completed 2 years of Ph.D. training in physiological optics and vision science, and is conducting psychophysical research on amblyopia with Dr. Dennis Levi. The specific training aims are to develop research skills and experience in (1) psychophysics, (2) computational vision, and (3) functional magnetic resonance imaging (fMRI). Amblyopia is a major cause of vision loss in infants and young children. Amblyopia results in well-documented losses in detection of luminance defined patterns that reflect abnormalities in primary visual cortex (VI). The Levi lab has recently shown losses in detection of contrast defined (second-order) patterns, which are widely believed to be processed in early extrastriate visual cortex (V2). The specific research aims test hypotheses about the mechanisms of these second-order spatial losses in amblyopia. Is the V2 loss associated with (la) loss of binocularity, abnormalities in (1b) compressive non-linearity, (1c) contrast gain control, (1d) long-range interactions, and (le) predictable by a quantitative model? Are abnormal mechanism(s) explained by (2) reduced second-order neuron population in V2? The research design includes psychophysical experiments (aims la - ld), computational modeling and simulation (aim le), and brain functional magnetic resonance imaging (fMRI) (aim 2) on normal and amblyopic human adults. Understanding amblyopia and its neural basis may lead to improved diagnosis and treatment.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23EY014261-03
Application #
6693058
Study Section
Special Emphasis Panel (ZEY1-VSN (02))
Program Officer
Oberdorfer, Michael
Project Start
2002-02-01
Project End
2004-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
3
Fiscal Year
2004
Total Cost
$90,142
Indirect Cost
Name
University of California Berkeley
Department
Type
Schools of Optometry/Ophthalmol
DUNS #
124726725
City
Berkeley
State
CA
Country
United States
Zip Code
94704
Wong, Erwin H; Levi, Dennis M; McGraw, Paul V (2005) Spatial interactions reveal inhibitory cortical networks in human amblyopia. Vision Res 45:2810-9