CANDIDATE: I aspire to become a leader in neonatal epidemiology and clinical trials, improving outcomes of neonates by furthering the empiric data available for evidence-based medicine. To succeed as an independent investigator, I strive to build on a strong epidemiologic background by furthering my training in large-scale prospective clinical research. I have a particular interest in the pulmonary outcomes of premature infants, and seek to be better able to measure these outcomes and collaborate with pulmonary specialists. ENVIRONMENT: Rainbow Babies &Children's Hospital and Case Western Reserve University provide an excellent environment for multidisciplinary collaboration and training in clinical research. The Division of Neonatology and the Division of Clinical Epidemiology and Biostatistics, lead by Dr. Richard Martin and Dr. Susan Redline respectively, have strong commitments to my career development. My home division, Neonatology, has an exceptional tradition of NIH-funded clinical research, including extensive experience with clinical trials and neonatal outcomes research. It is internationally known for clinical care and research, including its role in the NICHD Neonatal Research Network. RESEARCH:
The aims of this prospective cohort study of premature infants are to 1) describe the frequency of wheezing and gastroesophageal reflux (GER) in the first year of life 2) determine whether premature infants with GER are more likely to wheeze, 3) determine whether certain nutritional and feeding practices - formula-feeding, bottle-feeding in bed before sleep, and multi-vitamin use ~ are associated with wheezing, and 4) assess the reliability and validity of non-invasive measurements of wheezing and GER.

Public Health Relevance

The study focuses on larger, """"""""healthier"""""""" preterm infants (28-34 wks gestational age, no birth weight restrictions) who may be bearing an under-recognized burden of disease. The March of Dimes reports that of the 499,008 preterm births in the U.S. in 2003, only 1.4% were very low birth weight (VLBW, <1500g);the study population is more representative of premature infants in the U.S. than exclusively VLBW cohorts. A multidisciplinary approach focuses on potentially modifiable risk factors for wheezing, one of the most common complications of prematurity. This study will facilitate the design of future trials of therapies to prevent wheezing by identifying targetable risk factors and appropriate non-invasive measurement tools.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23HD056299-05
Application #
8128504
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Raju, Tonse N
Project Start
2007-09-28
Project End
2013-08-31
Budget Start
2011-09-01
Budget End
2013-08-31
Support Year
5
Fiscal Year
2011
Total Cost
$131,085
Indirect Cost
Name
Case Western Reserve University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Olicker, Arielle; Li, Hong; Tatsuoka, Curtis et al. (2016) Have Changing Palivizumab Administration Policies Led to More Respiratory Morbidity in Infants Born at 32-35 Weeks? J Pediatr 171:31-7
Hibbs, A M; Babineau, D C; Wang, X et al. (2015) Race differences in the association between multivitamin exposure and wheezing in preterm infants. J Perinatol 35:192-7
Hibbs, Anna Maria; Storfer-Isser, Amy; Rosen, Carol et al. (2014) Advanced sleep phase in adolescents born preterm. Behav Sleep Med 12:412-24
Wang, Katherine; Difiore, Juliann M; Martin, Richard J et al. (2013) Markers for severity of illness associated with decreased snoring in toddlers born ELGA. Acta Paediatr 102:e39-43
Boggs, Elizabeth; Minich, Nori; Hibbs, Anna Maria (2013) Performance of commonly used respiratory questionnaire items in a cohort of infants born preterm. Open J Pediatr 3:260-265
Hibbs, Anna Maria; Black, Dennis; Palermo, Lisa et al. (2010) Accounting for multiple births in neonatal and perinatal trials: systematic review and case study. J Pediatr 156:202-8
Walsh, Michele C; Hibbs, Anna Maria; Martin, Camilia R et al. (2010) Two-year neurodevelopmental outcomes of ventilated preterm infants treated with inhaled nitric oxide. J Pediatr 156:556-61.e1
Di Fiore, J; Arko, M; Herynk, B et al. (2010) Characterization of cardiorespiratory events following gastroesophageal reflux in preterm infants. J Perinatol 30:683-7
Golski, Catherine A; Rome, Ellen S; Martin, Richard J et al. (2010) Pediatric specialists' beliefs about gastroesophageal reflux disease in premature infants. Pediatrics 125:96-104
Di Fiore, Juliann M; Arko, Marina; Churbock, Kim et al. (2009) Technical limitations in detection of gastroesophageal reflux in neonates. J Pediatr Gastroenterol Nutr 49:177-82

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