Ismee Williams is an Assistant Professor in the Division of Pediatric Cardiology at Columbia University with a long-term goal to become an independent clinical investigator of perinatal contributors to neurodevelopmental outcomes in the congenital heart disease (CHD) population. Dr. Williams'short-term goal is to acquire the skill set and experience needed to launch her career. To date, Dr. Williams has benefitted greatly from the clinical research environment of Columbia University which includes the resources made available by the NIH-funded Clinical and Translational Science Award (CTSA). Dr. Williams trained in the conduct of patient oriented research and received a Masters in Biostatistics from the Mailman School of Public Health during the last two years of her fellowship. Dr. Williams was named a K12 TRANSFORM scholar during her first year as an attending and received a $50,000 CTSA sponsored pilot award the following year. Over the past year, Dr. Williams has directed a multidisciplinary feasibility study that is the basis for the proposed protocol to investigate potential risk factors associated with neurocognitive outcomes in patients with complex CHD. The proposed study is innovative in its intent to investigate perinatal markers of risk. Using a prospective observational cohort design, Dr. Williams will enroll 50 fetuses with CHD and 25 normal controls in order to 1) further characterize autonomic regulation in CHD fetuses, 2) test associations between fetal autonomic regulation and fetal cerebral blood flow, and 3) test associations between these two fetal measures and infant and toddler neurologic outcomes including autonomic regulation, cerebral function measured by high-density EEG, and neurodevelopment assessed by the Bayley Scale of Infant Development-III at 18-months. The career development plan includes a closely mentored program under the supervision of Dr. William Fifer, a developmental psychobiologist, with focused training in perinatal autonomic assessment. In addition, Dr. Philip Grieve will train Dr. Williams in the procedure of infant high-density EEG assessment. Increased understanding of these topics will allow Dr. Williams to become a more effective clinical perinatal investigator of neurodevelopmental outcomes in CHD.

Public Health Relevance

This study is important as: 1) CHD is the most common group of birth defects, 2) survival following CHD surgery is increasing, and 3) survivors of complex CHD often (>50%) have neurologic difficulties, including learning delay and mental retardation the causes of which are largely unknown. Identification of early markers of adverse neurologic outcomes will allow the implementation of timely preventative and therapeutic services.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23HD061601-04
Application #
8474805
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Oster-Granite, Mary Lou
Project Start
2010-07-01
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
4
Fiscal Year
2013
Total Cost
$131,085
Indirect Cost
$9,710
Name
Columbia University (N.Y.)
Department
Pediatrics
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Dadlez, Nina M; Brubaker, Sara G; Simpson, Lynn L et al. (2014) Impact of change in delivery practice on neonatal and maternal outcomes in cases of significant congenital heart disease. Congenit Heart Dis 9:368-72
Votava-Smith, Jodie K; Glickstein, Julie S; Simpson, Lynn L et al. (2014) Comparison of method of conception in fetuses undergoing echocardiography at a tertiary referral center. Prenat Diagn 34:445-9
Elder, Robert W; Quaegebeur, Jan M; Bacha, Emile A et al. (2013) Outcomes of the infant Ross procedure for congenital aortic stenosis followed into adolescence. J Thorac Cardiovasc Surg 145:1504-11
Landis, Benjamin J; Levey, Allison; Levasseur, Stephanie M et al. (2013) Prenatal diagnosis of congenital heart disease and birth outcomes. Pediatr Cardiol 34:597-605
Arya, Bhawna; Glickstein, Julie S; Levasseur, Stephanie M et al. (2013) Parents of children with congenital heart disease prefer more information than cardiologists provide. Congenit Heart Dis 8:78-85
Williams, Ismee A; Fifer, Carlen; Jaeggi, Edgar et al. (2013) The association of fetal cerebrovascular resistance with early neurodevelopment in single ventricle congenital heart disease. Am Heart J 165:544-550.e1
Tweddell, James S; Sleeper, Lynn A; Ohye, Richard G et al. (2012) Intermediate-term mortality and cardiac transplantation in infants with single-ventricle lesions: risk factors and their interaction with shunt type. J Thorac Cardiovasc Surg 144:152-9
Newburger, Jane W; Sleeper, Lynn A; Bellinger, David C et al. (2012) Early developmental outcome in children with hypoplastic left heart syndrome and related anomalies: the single ventricle reconstruction trial. Circulation 125:2081-91
Mirza, Fadi G; Bauer, Samuel T; Williams, Ismee A et al. (2012) Early fetal echocardiography: ready for prime time? Am J Perinatol 29:313-8
Williams, I A; Tarullo, A R; Grieve, P G et al. (2012) Fetal cerebrovascular resistance and neonatal EEG predict 18-month neurodevelopmental outcome in infants with congenital heart disease. Ultrasound Obstet Gynecol 40:304-9