The goal of this Mentored Patient-Oriented Research Career Development Award is to allow the applicant to develop the clinical research skills needed to pursue an independent, productive career in rehabilitation research. The applicant is a licensed physical therapist with a clinical doctorate completing her postdoctoral training in clinical investigation. This award will enhance the applicant's ability to investigate mechanisms underlying pre-arthritic hip disease (PAHD) by combining the applicant's existing expertise in musculoskeletal disorders with additional training in the kinematic assessment of lower extremity movement and advanced methods in patient-oriented research. The long-term objective is to develop effective rehabilitation strategies for people with PAHD that will prevent or delay the need for surgical or pharmacological intervention.
The specific aims of the proposed studies are designed to test the overall hypothesis that abnormal movement patterns contribute to the onset and persistence of PAHD. The proposed studies will 1) determine musculoskeletal differences between people with PAHD and people without PAHD, 2) determine the association among lower extremity movement patterns, muscle strength, bony abnormalities and self-report measures of functional ability, and 3) obtain preliminary data on the effectiveness of movement pattern training on measured impairments and functional ability in people with PAHD (exploratory treatment trial). People with PAHD and people without PAHD will participate in completing self-report measures of functional ability, tests of hip muscle strength, 3d movement assessment (kinematic) of specific functional movements and magnetic resonance imaging (MRI) to assess bony structure. Baseline data will be compared to determine if differences exist between people with PAHD and people without PAHD. To determine the best predictive variables of self- report functional ability, stepwise multivariable linear regression modeling will be used with the self-report measures as dependent variables and movement pattern abnormality, muscle strength and bony abnormalities as independent variables. Subjects with PAHD who wish to participate in a rehabilitation program will be provided motor pattern training including education to correct abnormal movement patterns during daily activities and strengthening of weak muscles thought to contribute to the abnormal movement patterns. Pretreatment and posttreatment measures will be compared to determine if improvements in impairments (abnormal movement pattern, muscle strength) correlate with an improvement in subjects'self-report of function. Results of this study will provide data to inform future mechanism-based studies of PAHD rehabilitation and injury prevention. In addition, data from the exploratory treatment trial will lead to a larger clinical trial to assess the effectiveness of movement pattern training.
Pre-arthritic hip disease (PAHD) is a major cause of hip dysfunction and activity limitation in young adults that, without proper management, may progress to hip osteoarthritis (OA). Effective treatment of PAHD is needed to improve function in the young adult and prevent or delay the onset of hip OA, however evidence related to treatment of PAHD is limited. This research will improve the understanding of factors that contribute to PAHD and will be the first study to assess the effectiveness of a rehabilitation strategy targeted at specific impairments in people with PAHD.
|Harris-Hayes, Marcie; Czuppon, Sylvia; Van Dillen, Linda R et al. (2016) Movement-Pattern Training to Improve Function in People With Chronic Hip Joint Pain: A Feasibility Randomized Clinical Trial. J Orthop Sports Phys Ther 46:452-61|
|Harris-Hayes, Marcie; Mueller, Michael J; Sahrmann, Shirley A et al. (2014) Persons with chronic hip joint pain exhibit reduced hip muscle strength. J Orthop Sports Phys Ther 44:890-8|
|Harris-Hayes, Marcie; Commean, Paul K; Patterson, Jacqueline D et al. (2014) Bony abnormalities of the hip joint: a new comprehensive, reliable and radiation-free measurement method using magnetic resonance imaging. J Hip Preserv Surg 1:62-70|
|Harris-Hayes, Marcie; Willis, Allison W; Klein, Sandra E et al. (2014) Relative mortality in U.S. Medicare beneficiaries with Parkinson disease and hip and pelvic fractures. J Bone Joint Surg Am 96:e27|
|Czuppon, Sylvia; Racette, Brad A; Klein, Sandra E et al. (2014) Variables associated with return to sport following anterior cruciate ligament reconstruction: a systematic review. Br J Sports Med 48:356-64|
|Enseki, Keelan; Harris-Hayes, Marcie; White, Douglas M et al. (2014) Nonarthritic hip joint pain. J Orthop Sports Phys Ther 44:A1-32|
|Harris-Hayes, Marcie; Steger-May, Karen; Koh, Christine et al. (2014) Classification of lower extremity movement patterns based on visual assessment: reliability and correlation with 2-dimensional video analysis. J Athl Train 49:304-10|
|Kuhn, Margaret; Harris-Hayes, Marcie; Steger-May, Karen et al. (2013) Total hip arthroplasty in patients 50 years or less: do we improve activity profiles? J Arthroplasty 28:872-6|
|Harris-Hayes, Marcie; McDonough, Christine M; Leunig, Michael et al. (2013) Clinical outcomes assessment in clinical trials to assess treatment of femoroacetabular impingement: use of patient-reported outcome measures. J Am Acad Orthop Surg 21 Suppl 1:S39-46|
|Harris-Hayes, Marcie; Steger-May, Karen; Pashos, Gail et al. (2012) Stride activity level in young and middle-aged adults with hip disorders. Physiother Theory Pract 28:333-43|
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