Candidate: Karen Margolis, M.D., M.P.H., is a member of the Berman Center for Outcomes and Clinical Research at the Minneapolis Medical Research Foundation, and staff physician at Hennepin County Medical Center, a teaching hospital affiliated with the University of Minnesota. Dr. Margolis is interested in finding interventions which bring patients, physicians and the system of care together to implement effective medical care, specifically in the area of cardiovascular disease prevention. Career Objectives. Dr. Margolis' immediate career objectives include: (1) advanced course work in epidemiology, biostatistics, health services research, study design and analysis; (2) work with the Berman Center multi-center clinical trials and prospective studies; (3) work with mentor to develop and evaluate research direction, skills and experience; (4) obtain funding for and implement pilot and full-scale studies of randomized trial of physician incentives for improving the control of hypertension in a managed care organization; and (5) develop other related research projects. Dr. Margolis' long-term career objectives include attaining independence as an investigator in the field of patient-oriented cardiovascular disease prevention research and incorporating the theme of physician and patient adoption of effective interventions in a system of care for the prevention of cardiovascular disease morbidity and mortality. Research Plan. During the five year period of the award, Dr. Margolis plans to undertake at least one major clinical trial preceded by a pilot study for that trial. The clinical trial and pilot study are entitled """"""""Program for Improving the Treatment and Control of Hypertension (PITCH)"""""""" and will involve testing the hypothesis that clinics in a managed care organization receiving funding to design their own program for improving the control of hypertension will have a higher percentage of hypertensives with controlled blood pressure compared to both clinics given similar funding for financial incentives (provided directly to physicians based on performance) and control clinics given no financial incentives. Dr. Margolis also has planned several other related projects which include: (1) study of patient attitudes towards physician financial incentives and satisfaction with care in PITCH; (2) study of impact of physician financial incentives in PITCH on medical care other than hypertension; and (3) the role of patient health state preferences in acceptance of hypertension treatment and control of hypertension.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23HL003996-03
Application #
6388522
Study Section
Special Emphasis Panel (ZHL1-CSR-F (F1))
Program Officer
Schucker, Beth
Project Start
1999-06-01
Project End
2004-05-31
Budget Start
2001-06-01
Budget End
2002-05-31
Support Year
3
Fiscal Year
2001
Total Cost
$127,845
Indirect Cost
Name
Minneapolis Medical Research Fdn, Inc.
Department
Type
DUNS #
City
Minneapolis
State
MN
Country
United States
Zip Code
55415
Margolis, Karen L; Adami, Hans-Olov; Luo, Juhua et al. (2007) A prospective study of oral contraceptive use and risk of myocardial infarction among Swedish women. Fertil Steril 88:310-6
Margolis, Karen L; Manson, JoAnn E; Greenland, Philip et al. (2005) Leukocyte count as a predictor of cardiovascular events and mortality in postmenopausal women: the Women's Health Initiative Observational Study. Arch Intern Med 165:500-8
Margolis, Karen L; Mucci, Lorelei; Braaten, Tonje et al. (2005) Physical activity in different periods of life and the risk of breast cancer: the Norwegian-Swedish Women's Lifestyle and Health cohort study. Cancer Epidemiol Biomarkers Prev 14:27-32
Margolis, Karen L; Rolnick, Sharon J; Fortman, Kristine K et al. (2005) Self-reported hypertension treatment beliefs and practices of primary care physicians in a managed care organization. Am J Hypertens 18:566-71
Margolis, K L; Bonds, D E; Rodabough, R J et al. (2004) Effect of oestrogen plus progestin on the incidence of diabetes in postmenopausal women: results from the Women's Health Initiative Hormone Trial. Diabetologia 47:1175-87
Margolis, Karen L; Kerani, Roxanne Pieper; McGovern, Paul et al. (2002) Risk factors for motor vehicle crashes in older women. J Gerontol A Biol Sci Med Sci 57:M186-91
Rolnick, Sharon J; Margolis, Karen L; Fortman, Kristine K et al. (2002) How acceptable are financial incentives and written feedback for improving hypertension control? Perspectives from physicians, clinic administrators, and patients. Am J Manag Care 8:441-7