A fundamental question faced by physicians treating acute decompensated heart failure (ADHF) is 'When has treatment worked sufficiently for safe discharge, and who requires further treatment?'Patients with ADHF have a high incidence of morbidity and mortality. Current guidelines for emergency department (ED) and hospital disposition of patients with ADHF are based on limited empirical evidence. This creates clinical uncertainty regarding disposition, leads to prolonged hospitalizations, higher costs and increased resource consumption. Conducting a project to answer this question, in combination with carefully planned didactics and mentoring from distinguished researchers, will allow me to develop as an independent clinical investigator with a primary focus on decision making in patients with ADHF. The ED is the portal of entry for the majority of ADHF admissions and presents fertile ground for prospectively studying decision making.
My specific aims are: 1) to further develop knowledge in clinical research, advanced modeling, and decision sciences to advance my development as an independent clinical investigator and 2) to develop a prediction rule from readily available clinical data that helps physicians identify ADHF patients for whom early discharge from the ED and hospital is safe after treatment is initiated. In recognition of the importance of the ED in ADHF care, the NHLBI is supporting our observational cohort study of 1800 ED patients to develop a prediction rule for initial risk-stratification (STRATIFY- 1R01HL088459). To complete my aim, I will collect additional data on a subset of 500 patients from STRATIFY whose baseline data is collected within 1 hour of ED therapy. In addition to the baseline data from STRATIFY, the current proposal will collect clinical and laboratory data 2-4 hours, 12-24 hours and 96 hours after treatment is begun. We will also interview patients to measure social and behavioral variables. We will use this additional data to develop a second prediction rule to assist physicians in identifying patients safe for early ED and hospital discharge after therapy is begun. This project is an ideal vehicle for practical application of didactic knowledge gained, offers an intensive clinical research experience, and promises to generate extensive preliminary data to fully expand a long-term research program. My clinical research, didactic program and advanced biostatistical and modeling coursework will be supervised by a highly qualified, multi-disciplinary team of talented individuals, Building from my completed Outcomes Research fellowship and previous research experience, this proposal will allow me to mature as a clinical investigator, develop a prediction rule for decision making in ADHF, and engender evidence- based research in a disease process with tremendous healthcare system implications.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23HL085387-06
Application #
8262163
Study Section
Special Emphasis Panel (ZHL1-CSR-R (M1))
Program Officer
Scott, Jane
Project Start
2008-09-01
Project End
2014-04-30
Budget Start
2012-05-01
Budget End
2014-04-30
Support Year
6
Fiscal Year
2012
Total Cost
$151,016
Indirect Cost
$11,186
Name
Vanderbilt University Medical Center
Department
None
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Self, Wesley H; Storrow, Alan B; Hartmann, Oliver et al. (2016) Plasma bioactive adrenomedullin as a prognostic biomarker in acute heart failure. Am J Emerg Med 34:257-62
Alexander, Pauline; Alkhawam, Lora; Curry, Jason et al. (2015) Lack of evidence for intravenous vasodilators in ED patients with acute heart failure: a systematic review. Am J Emerg Med 33:133-41
Collins, Sean; Storrow, Alan B; Albert, Nancy M et al. (2015) Early management of patients with acute heart failure: state of the art and future directions. A consensus document from the society for academic emergency medicine/heart failure society of America acute heart failure working group. J Card Fail 21:27-43
Collins, Sean P; Storrow, Alan B; Levy, Phillip D et al. (2015) Early management of patients with acute heart failure: state of the art and future directions--a consensus document from the SAEM/HFSA acute heart failure working group. Acad Emerg Med 22:94-112
Chioncel, Ovidiu; Ambrosy, Andrew P; Filipescu, Daniela et al. (2015) Patterns of intensive care unit admissions in patients hospitalized for heart failure: insights from the RO-AHFS registry. J Cardiovasc Med (Hagerstown) 16:331-40
Collins, Sean P; Jenkins, Cathy A; Harrell Jr, Frank E et al. (2015) Identification of Emergency Department Patients With Acute Heart Failure at Low Risk for 30-Day Adverse Events: The STRATIFY Decision Tool. JACC Heart Fail 3:737-47
Behringer, Tiffany S; Collins, Sean (2015) Non-invasive Ventilation: A Gimmick or Does it Really Affect Outcomes? Curr Emerg Hosp Med Rep 3:62-65
Moellman, Joseph J; Bernstein, Jonathan A; Lindsell, Christopher et al. (2014) A consensus parameter for the evaluation and management of angioedema in the emergency department. Acad Emerg Med 21:469-84
De Marco, Margot; D'Auria, Raffaella; Rosati, Alessandra et al. (2014) BAG3 protein in advanced-stage heart failure. JACC Heart Fail 2:673-5
Storrow, Alan B; Jenkins, Cathy A; Self, Wesley H et al. (2014) The burden of acute heart failure on U.S. emergency departments. JACC Heart Fail 2:269-77

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