Jarett D. Berry, MD, has received an appointment effective July, 2008 in the Department of Preventive Medicine (primary) and the Department of Medicine, Division of Cardiology (secondary) at Northwestern University. The candidate's long-term goal is to combine a career in cardiovascular medicine with research independence in the study of plaque characterization using magnetic resonance imaging (MRI) methods in population studies. The candidate's previous research experience in cardiovascular disease epidemiology has focused on alternative statistical modeling strategies for risk estimation. Emerging imaging methods such as carotid MRI can accurately quantify and characterize plaque burden (i.e. "the vulnerable plaque"). However, it remains unclear exactly how to incorporate plaque imaging data into clinical decision-making because little is known regarding its association with traditional risk factors across the lifespan. The proposed career development plan incorporates advanced training in biomedical engineering, MRI image acquisition, MRI image analysis, and data analysis through a combination of structured coursework, seminars, and training experiences. The present proposal is an ancillary study to an existing NHLBI-funded study, the "Chicago Healthy Aging Study" (CHAS) in which individuals with risk factors measured at age 25- 44 years in the 1960s will be reexamined for the presence of coronary calcium, inflammation, and physical functioning decades later at ages 65-79 years. Because risk factors were measured in these participants at a young age, the addition of carotid MRI measures to the CHAS provides a unique and cost-effective opportunity to compare the association between risk factors measured at ages 25-44 years and carotid MRI plaque characteristics at age 65-79 years. The primary specific aims include: (1) to determine the association of low-risk (LR) status at ages 25-44 years with MRI measures of carotid atherosclerosis at ages 65-79 years;(2) to determine the association of MRI measures of carotid atherosclerosis measured at ages 65-79 years with concurrent measures of subclinical atherosclerosis in the coronary and peripheral arterial beds. This research will fill critical gaps in our knowledge of the long-term consequences of LR status, which may ultimately lead to improvements in public health and preventive strategies.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Mentored Patient-Oriented Research Career Development Award (K23)
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Special Emphasis Panel (ZHL1-CSR-R (O1))
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Scott, Jane
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University of Texas Sw Medical Center Dallas
Internal Medicine/Medicine
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United States
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Petr, Elisabeth Joye; Ayers, Colby R; Pandey, Ambarish et al. (2014) Perceived lifetime risk for cardiovascular disease (from the Dallas Heart Study). Am J Cardiol 114:53-8
Wickramasinghe, Chanaka D; Ayers, Colby R; Das, Sandeep et al. (2014) Prediction of 30-year risk for cardiovascular mortality by fitness and risk factor levels: the Cooper Center Longitudinal Study. Circ Cardiovasc Qual Outcomes 7:597-602
Kulinski, Jacquelyn P; Khera, Amit; Ayers, Colby R et al. (2014) Association between cardiorespiratory fitness and accelerometer-derived physical activity and sedentary time in the general population. Mayo Clin Proc 89:1063-71
Paixao, Andre R M; Berry, Jarett D (2014) Beyond Framingham and coronary calcium: predicted lifetime risk identifies unfavorable risk trajectories. J Nucl Cardiol 21:42-5
Brinker, Stephanie K; Pandey, Ambarish; Ayers, Colby R et al. (2014) Association of cardiorespiratory fitness with left ventricular remodeling and diastolic function: the Cooper Center Longitudinal Study. JACC Heart Fail 2:238-46
Defina, Laura F; Willis, Benjamin L; Radford, Nina B et al. (2013) The association between midlife cardiorespiratory fitness levels and later-life dementia: a cohort study. Ann Intern Med 158:162-8
Gupta, Sachin; Matulevicius, Susan A; Ayers, Colby R et al. (2013) Left atrial structure and function and clinical outcomes in the general population. Eur Heart J 34:278-85
Berry, Jarett D; Pandey, Ambarish; Gao, Ang et al. (2013) Physical fitness and risk for heart failure and coronary artery disease. Circ Heart Fail 6:627-34
Berry, Jarett D; Dyer, Alan; Cai, Xuan et al. (2012) Lifetime risks of cardiovascular disease. N Engl J Med 366:321-9
Vigen, Rebecca; Ayers, Colby; Willis, Benjamin et al. (2012) Association of cardiorespiratory fitness with total, cardiovascular, and noncardiovascular mortality across 3 decades of follow-up in men and women. Circ Cardiovasc Qual Outcomes 5:358-64

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