The purpose of this proposal is to foster the scientific development of Angela Taylor, M.D. as she develops an independent clinical research career. The University of Virginia will provide Dr. Taylor with the ideal setting under the mentorship of Dr. Christopher Kramer in which to investigate the imaging and treatment of early coronary artery disease in diabetes. Type II diabetes has become an epidemic in the United States. Death from cardiovascular disease is 2 to 4 fold the general population. Recent trials have demonstrated that traditional risk factors alone are not completely predictive of disease burden as measured with current noninvasive imaging technology particularly early in the disease process. Overt coronary artery disease is preceded by abnormalities in myocardial microvascular function and nonocclusive plaque accumulation in the artery wall both of which can be measured invasively. It has been shown that risl Specific aims i nclude demonstrating that risk factors for coronary artery disease predict invasive and noninvasive measurements, that improvements in risk factors result in improvements in invasive and noninvasive measurements, and that CMR predicts invasive findings.

Public Health Relevance

An eariier noninvasive mechanism of detection of cardiovascular disease will provide the potential to determine which risk factors have the greatest effect early in the disease process thus tailoring therapy and reducing costs, to offer a safer diagnostic mechanism, and to treat coronary disease eariier preventing future events thus contributing to significant improvements in public health.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23HL093118-04
Application #
8269141
Study Section
Special Emphasis Panel (ZHL1-CSR-R (M1))
Program Officer
Scott, Jane
Project Start
2009-09-01
Project End
2014-05-31
Budget Start
2012-06-01
Budget End
2013-05-31
Support Year
4
Fiscal Year
2012
Total Cost
$126,895
Indirect Cost
$7,650
Name
University of Virginia
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
065391526
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Manichaikul, Ani; Rich, Stephen S; Perry, Heather et al. (2014) A functionally significant polymorphism in ID3 is associated with human coronary pathology. PLoS One 9:e90222
Bunch, T Jared; Darby, Andy; May, Heidi T et al. (2012) Efficacy and safety of ventricular tachycardia ablation with mechanical circulatory support compared with substrate-based ablation techniques. Europace 14:709-14
Enkiri, Sean A; Taylor, Angela M; Keeley, Ellen C et al. (2010) Coronary angiography is a better predictor of mortality than noninvasive testing in patients evaluated for renal transplantation. Catheter Cardiovasc Interv 76:795-801