This application for a Mentored Patient-Oriented Research Career Development Award (K23) is a new submission by a new investigator. The candidate proposes a program of research and training with the following goals: 1) to gain expertise in the design and conduct of randomized clinical trials (e.g., research design, study administration, biostatistics) that will enhance the quality of her scientific work throughout her career;2) to deepen her understanding of the etiology and progression of cardiovascular disease, as well as the relationship of obesity and depression to incident cardiovascular disease (CVD) risk factors;3) to increase her understanding of the etiology and treatment of obesity and depression, and to develop skills to objectively assess a treatment that targets each disorder;and 4) to gain further training in the responsible conduct of research and ethical issues related specifically to patients with comorbid obesity and other disorders. This training will prepare the candidate to conduct a randomized controlled trial that will establish initial effect size, and feasibility, of a new treatment that concurrently targets obesity and depression. The intervention is designed to demonstrate that: 1) obese, depressed individuals can achieve clinically significant weight losses;and 2) that weight reduction is associated with favorable changes in CVD risk factors and mood. Obesity and depression are independent risk factors for incident CVD. Weight losses of moderate magnitude (e.g., ~5% of initial weight) been shown to improve risk factors for CVD, yet depressed individuals are routinely screened out of weight loss trials. This practice stems from concern that weight reduction may exacerbate symptoms of depression, despite the lack of empirical evidence to support this idea. Thus, it is unknown whether obese individuals with clinical depression can safely undertake weight reduction, and whether there are concomitant improvements in CVD risk factors. Participants (n = 50) who are both obese and depressed, with at least two risk factors for CVD, will be randomly assigned to group cognitive-behavioral therapy for the treatment of depression combined with behavior modification for weight loss (Combined Treatment), or to a combination of GCBT and a non-dieting approach to weight loss (GCBT-ND). We hypothesize that the Combined Treatment will concurrently induce weight loss, improve mood, and result in improvements in CVD risk factors in obese, depressed individuals. Persons receiving Combined Treatment are expected to lose significantly more weight than those in the GCBT-ND condition after 20 weeks of treatment. These participants are also expected to show greater improvements in CVD risk factors than those receiving GCBT-ND. Mood is expected to improve in both conditions, as all participants will receive group CBT for depression. The proposed study will be the first randomized controlled trial to assess whether weight loss and improvements in CVD risk factors can be effectively achieved in obese individuals with clinical depression. The research and training experiences described in this proposal will prepare the candidate for continued independent clinical research in the relationships of obesity and depression to cardiovascular disease.

Public Health Relevance

Obesity and depression independently increase the risk of developing cardiovascular disease. Weight loss has been shown to improve these risks, yet obese, depressed patients are routinely screened out of weight loss trials. This leaves large numbers of patients without appropriate treatment, given that both obesity and depression are serious public health concerns. The current study proposes to develop a novel intervention that will concurrently target obesity and depression in obese, depressed participants. We expect significant reductions in weight, as well as improvements in cardiovascular disease risk factors and symptoms of depression.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23HL109235-03
Application #
8463237
Study Section
Special Emphasis Panel (ZHL1-CSR-X (M1))
Program Officer
Czajkowski, Susan
Project Start
2011-08-17
Project End
2016-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
3
Fiscal Year
2013
Total Cost
$139,058
Indirect Cost
$10,301
Name
University of Pennsylvania
Department
Psychiatry
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Faulconbridge, Lucy F; Bechtel, Colleen F (2014) Depression and Disordered Eating in the Obese Person. Curr Obes Rep 3:127-36
Faulconbridge, Lucy F; Wadden, Thomas A; Rubin, Richard R et al. (2012) One-year changes in symptoms of depression and weight in overweight/obese individuals with type 2 diabetes in the Look AHEAD study. Obesity (Silver Spring) 20:783-93
Faulconbridge, Lucy F; Hayes, Matthew R (2011) Regulation of energy balance and body weight by the brain: a distributed system prone to disruption. Psychiatr Clin North Am 34:733-45