There is growing evidence from epidemiological and experimental studies that individuals who Apart from these larger literatures, there are a few studies that have investigated the short sleeper phenomenon directly and more intensively, but these do not address health-related outcomes. Research: The study proposed within this K-Award is intended to be a first step in a larger program of research that will serve to bridge between the epidemiologic and experimental domains. This will ultimately allow for (1) Identification of individuals that are at risk for the ill effects of short sleep, (2) Development f behavioral interventions aimed at ameliorating adverse cardiometabolic effects of insufficient sleep, and (3) Detection of individuals that are true short sleepers and the qualities that make them resistant to the ill effects of short sleep. The proposed study utilizes a large-scale survey (n=1200) to recruit 60 subjects (40 short and 20 normal duration sleepers) to be assessed in two short sleep are at risk for a number of negative cardiovascular and metabolic health outcomes. These studies, in evaluated samples sleeper short The limitations. have seminal, and groundbreaking while epidemiological sleeper short aggregate and assessments item) (single nonstandard use often studies samples that are likely very heterogeneous. The experimental studies, while highly controlled and populated by homogenous sleep partial to similar more is that state a produce that manipulations engage samples, deprivation than naturally-occurring short sleep. Phase 1, a 2-week home-based study, will be used to prospectively corroborate subjects'survey responses regarding sleep duration, to screen for sleep-disordered breathing, and to gather blood pressure data. Phase-2, a 3-night, in-lab study, will be used to gather standardized measures of sleep continuity and sleep architecture (via polysomnography), sleepiness (via a Multiple Sleep Latency Test), psychomotor performance (via the Psychomotor Vigilance Task), aortic glucose homeostasis (via an Oral Glucose Tolerance Test) and biomarkers including atherogenic lipoproteins (i.e., HDL and LDL), IL-6, CRP, leptin and ghrelin. The lab-based data will be used to (1) Determine whether short and normal duration sleepers differ on objective measures of sleep, sleepiness/performance, and cardiometabolic function, and (2) Explore (in a preliminary way) whether subgroups within the short sleeper cohort account for the association between sleep duration and health. pulse wave velocity (via arterial tonometry), Training: This component of the K23 is comprised of the didactic and mentored experiences required to enable the applicant to develop the proposed program of research. The training plan builds upon the applicant's background in Health Psychology and provides him the necessary training in cardiovascular and metabolic physiology to address if and how the behavioral phenotype of short sleep is associated with negative health outcomes. The pedagogic approach includes routine one-on-one mentorship, course work, lab-based practica, and completion of a Masters degree program in Translational Research.

Public Health Relevance

Data from the present study will set the stage for the identification of short sleeper phenotypes which, in turn, may allow for the distinction between those that that require an intervention and those whose phenotype include relative resistance to the effects of shorter than average sleep. With respect to the former, this will lead to the development of behavioral interventions. With respect to the latter, a firm understanding of the factors that allow for true short sleep may result in the development of strategies to assist normal sleepers to optimally perform when required to adhere to short sleep schedules.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Mentored Patient-Oriented Research Career Development Award (K23)
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Special Emphasis Panel (ZHL1-CSR-X (M1))
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Twery, Michael
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University of Pennsylvania
Schools of Medicine
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Chakravorty, Subhajit; Grandner, Michael A; Mavandadi, Shahrzad et al. (2014) Suicidal ideation in veterans misusing alcohol: relationships with insomnia symptoms and sleep duration. Addict Behav 39:399-405
Grandner, Michael A; Jackson, Nicholas; Gooneratne, Nalaka S et al. (2014) The development of a questionnaire to assess sleep-related practices, beliefs, and attitudes. Behav Sleep Med 12:123-42
Petrov, Megan E; Howard, Virginia J; Kleindorfer, Dawn et al. (2014) Over-the-counter and prescription sleep medication and incident stroke: the REasons for Geographic and Racial Differences in Stroke study. J Stroke Cerebrovasc Dis 23:2110-6
Whinnery, Julia; Jackson, Nicholas; Rattanaumpawan, Pinyo et al. (2014) Short and long sleep duration associated with race/ethnicity, sociodemographics, and socioeconomic position. Sleep 37:601-11
Grandner, Michael A (2014) Addressing sleep disturbances: an opportunity to prevent cardiometabolic disease? Int Rev Psychiatry 26:155-76
Pak, Victoria M; Grandner, Michael A; Pack, Allan I (2014) Circulating adhesion molecules in obstructive sleep apnea and cardiovascular disease. Sleep Med Rev 18:25-34
Grandner, Michael A; Jackson, Nicholas; Gerstner, Jason R et al. (2014) Sleep symptoms associated with intake of specific dietary nutrients. J Sleep Res 23:22-34
Grandner, Michael A; Knutson, Kristen L; Troxel, Wendy et al. (2014) Implications of sleep and energy drink use for health disparities. Nutr Rev 72 Suppl 1:14-22
Grandner, Michael A; Chakravorty, Subhajit; Perlis, Michael L et al. (2014) Habitual sleep duration associated with self-reported and objectively determined cardiometabolic risk factors. Sleep Med 15:42-50
Grandner, Michael A; Petrov, Megan E Ruiter; Rattanaumpawan, Pinyo et al. (2013) Sleep symptoms, race/ethnicity, and socioeconomic position. J Clin Sleep Med 9:897-905; 905A-905D

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