There is growing evidence from epidemiological and experimental studies that individuals who Apart from these larger literatures, there are a few studies that have investigated the short sleeper phenomenon directly and more intensively, but these do not address health-related outcomes. Research: The study proposed within this K-Award is intended to be a first step in a larger program of research that will serve to bridge between the epidemiologic and experimental domains. This will ultimately allow for (1) Identification of individuals that are at risk for the ill effects of short sleep, (2) Development f behavioral interventions aimed at ameliorating adverse cardiometabolic effects of insufficient sleep, and (3) Detection of individuals that are true short sleepers and the qualities that make them resistant to the ill effects of short sleep. The proposed study utilizes a large-scale survey (n=1200) to recruit 60 subjects (40 short and 20 normal duration sleepers) to be assessed in two short sleep are at risk for a number of negative cardiovascular and metabolic health outcomes. These studies, in evaluated samples sleeper short The limitations. have seminal, and groundbreaking while epidemiological sleeper short aggregate and assessments item) (single nonstandard use often studies samples that are likely very heterogeneous. The experimental studies, while highly controlled and populated by homogenous sleep partial to similar more is that state a produce that manipulations engage samples, deprivation than naturally-occurring short sleep. Phase 1, a 2-week home-based study, will be used to prospectively corroborate subjects'survey responses regarding sleep duration, to screen for sleep-disordered breathing, and to gather blood pressure data. Phase-2, a 3-night, in-lab study, will be used to gather standardized measures of sleep continuity and sleep architecture (via polysomnography), sleepiness (via a Multiple Sleep Latency Test), psychomotor performance (via the Psychomotor Vigilance Task), aortic glucose homeostasis (via an Oral Glucose Tolerance Test) and biomarkers including atherogenic lipoproteins (i.e., HDL and LDL), IL-6, CRP, leptin and ghrelin. The lab-based data will be used to (1) Determine whether short and normal duration sleepers differ on objective measures of sleep, sleepiness/performance, and cardiometabolic function, and (2) Explore (in a preliminary way) whether subgroups within the short sleeper cohort account for the association between sleep duration and health. pulse wave velocity (via arterial tonometry), Training: This component of the K23 is comprised of the didactic and mentored experiences required to enable the applicant to develop the proposed program of research. The training plan builds upon the applicant's background in Health Psychology and provides him the necessary training in cardiovascular and metabolic physiology to address if and how the behavioral phenotype of short sleep is associated with negative health outcomes. The pedagogic approach includes routine one-on-one mentorship, course work, lab-based practica, and completion of a Masters degree program in Translational Research.

Public Health Relevance

Data from the present study will set the stage for the identification of short sleeper phenotypes which, in turn, may allow for the distinction between those that that require an intervention and those whose phenotype include relative resistance to the effects of shorter than average sleep. With respect to the former, this will lead to the development of behavioral interventions. With respect to the latter, a firm understanding of the factors that allow for true short sleep may result in the development of strategies to assist normal sleepers to optimally perform when required to adhere to short sleep schedules.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Mentored Patient-Oriented Research Career Development Award (K23)
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Special Emphasis Panel (ZHL1-CSR-X (M1))
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Twery, Michael
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University of Pennsylvania
Schools of Medicine
United States
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Grandner, Michael A; Malhotra, Atul (2017) Connecting insomnia, sleep apnoea and depression. Respirology 22:1249-1250
Bastien, Celyne H; Ellis, Jason G; Grandner, Michael (2017) CBT-I and the short sleep duration insomnia phenotype: a comment on Bathgate, Edinger and Krystal. Ann Transl Med 5:335
Perlis, Michael L; Grandner, Michael A; Brown, Gregory K et al. (2016) Nocturnal Wakefulness as a Previously Unrecognized Risk Factor for Suicide. J Clin Psychiatry 77:e726-33
Truong, Kimberly K; Lam, Michael T; Grandner, Michael A et al. (2016) Timing Matters: Circadian Rhythm in Sepsis, Obstructive Lung Disease, Obstructive Sleep Apnea, and Cancer. Ann Am Thorac Soc 13:1144-54
Perlis, Michael L; Grandner, Michael A; Chakravorty, Subhajit et al. (2016) Suicide and sleep: Is it a bad thing to be awake when reason sleeps? Sleep Med Rev 29:101-7
Grandner, Michael A; Williams, Natasha J; Knutson, Kristen L et al. (2016) Sleep disparity, race/ethnicity, and socioeconomic position. Sleep Med 18:7-18
Orzech, Kathryn M; Grandner, Michael A; Roane, Brandy M et al. (2016) Digital media use in the 2 h before bedtime is associated with sleep variables in university students. Comput Human Behav 55:43-50
Grandner, Michael A; Alfonso-Miller, Pamela; Fernandez-Mendoza, Julio et al. (2016) Sleep: important considerations for the prevention of cardiovascular disease. Curr Opin Cardiol 31:551-65
Chaudhary, Ninad S; Grandner, Michael A; Jackson, Nicholas J et al. (2016) Caffeine consumption, insomnia, and sleep duration: Results from a nationally representative sample. Nutrition 32:1193-9
Grandner, Michael A; Seixas, Azizi; Shetty, Safal et al. (2016) Sleep Duration and Diabetes Risk: Population Trends and Potential Mechanisms. Curr Diab Rep 16:106

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