The objective of this application is to support the career development of Dr. Alicia Gerke. Dr. Gerke's long term career goal is to become a nationally recognized clinical investigator in identifying clinical and genetic risk factors for diagnosis and prognosis of rare diseases using novel internet-based research techniques. Dr. Gerke has assembled a team of experienced mentors (Drs. James Torner, Jeffrey Murray, Philip Polgreen, and Martha Monick) who bring expertise in complementary methodological areas and experience in nurturing young investigators. Using a recently developed national sarcoidosis registry, she will describe characteristics of the disease across the nation and identify clinical and genetic markers associated with outcomes. During the award, Dr. Gerke will become an expert in: 1) Patient-based investigation using internet-assisted (e-health) research, 2) Advanced clinical epidemiology methods for use in internet research, and 3) Identifying genetic markers of risk for disease prognosis and outcomes. These goals will be accomplished by coursework, readings, and research experiences guided by her mentors. Because clinical trials are difficult to perform in rare diseases such as sarcoidosis, much of clinical management is dictated by expert opinion. To date, the outcomes of varying diagnostic and treatment practices across the nation are largely unknown. Dr. Gerke will be using a sarcoidosis disease registry to aggregate data on a large national cohort of sarcoidosis patients in order to, first, understand the variability of diagnostic and treatment practices across the nation, and then, to identify clinical and genetic markers associated with progressive disease requiring long-term treatment.
For Aim 1, Dr. Gerke will be expanding recruitment on an existing registry using internet and e-health based research approaches.
Aim 2 will use registry data to define the pathways of diagnosis for sarcoidosis patients and establish risks associated with delays in diagnosis.
Aim 3 will describe the treatment variability across the nation and identify treatment related practices associated with adverse outcomes.
Aim 4 will be using DNA specimens from the registry biorepository to identify DNA methylation patterns that are associated with diagnosis and prognosis of patients with sarcoidosis. These projects are important to explore the characteristics of sarcoidosis patients on a national scale and identifying appropriate clinical an genetic markers of appropriate phenotypes for future clinical trials. Completion of these aims will provide the foundation for an independent research career for Dr. Gerke. Dr. Gerke's mentors and institution are committed to her success with resources and the environment in place to facilitate her career development.
Because clinical trials are difficult to perform in rare diseases such as sarcoidosis, there is a lack of knowledge regarding diagnostic and treatment approaches and how to predict which patients will need prolonged therapy. The goal of this research proposal is to use a national registry to characterize the disease and improve the management and treatment of patients with sarcoidosis.
|Vargas Buonfiglio, Luis G; Borcherding, Jennifer A; Frommelt, Mark et al. (2018) Airway surface liquid from smokers promotes bacterial growth and biofilm formation via iron-lactoferrin imbalance. Respir Res 19:42|
|Gerke, Alicia K; Tang, Fan; Cozier, Yvette C et al. (2017) A web-based registry for patients with sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 34:26-34|
|Jain, Snigdha; Khera, Rohan; Girotra, Saket et al. (2017) Comparative Effectiveness of Pharmacologic Interventions for Pulmonary Arterial Hypertension: A Systematic Review and Network Meta-Analysis. Chest 151:90-105|
|Vargas Buonfiglio, Luis G; Cano, Marlene; Pezzulo, Alejandro A et al. (2017) Effect of vitamin D3 on the antimicrobial activity of human airway surface liquid: preliminary results of a randomised placebo-controlled double-blind trial. BMJ Open Respir Res 4:e000211|
|Gerke, Alicia K; Judson, Marc A; Cozier, Yvette C et al. (2017) Disease Burden and Variability in Sarcoidosis. Ann Am Thorac Soc 14:S421-S428|
|Vargas Buonfiglio, Luis G; Mudunkotuwa, Imali A; Abou Alaiwa, Mahmoud H et al. (2017) Effects of Coal Fly Ash Particulate Matter on the Antimicrobial Activity of Airway Surface Liquid. Environ Health Perspect 125:077003|
|Chan, Kung-Sik; Jiao, Feiran; Mikulski, Marek A et al. (2016) Novel Logistic Regression Model of Chest CT Attenuation Coefficient Distributions for the Automated Detection of Abnormal (Emphysema or ILD) Versus Normal Lung. Acad Radiol 23:304-14|
|Khera, Rohan; Cram, Peter; Lu, Xin et al. (2015) Trends in the use of percutaneous ventricular assist devices: analysis of national inpatient sample data, 2007 through 2012. JAMA Intern Med 175:941-50|
|Gerke, Alicia K; Tang, Fan; Cavanaugh, Joseph E et al. (2015) Increased trend in extracorporeal membrane oxygenation use by adults in the United States since 2007. BMC Res Notes 8:686|
|Gerke, Alicia K; Pezzulo, Alejandro A; Tang, Fan et al. (2014) Effects of vitamin D supplementation on alveolar macrophage gene expression: preliminary results of a randomized, controlled trial. Multidiscip Respir Med 9:18|
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