The purpose of this Mentored Patient-Oriented Research Career Development proposal is to request support to develop an integrated affective and cognitive neuroscience approach to investigate affective deficits in schizophrenia. The primary aim of the research is to functionally assess neural circuitry that is critically involved in basic processes linking emotional and cognitive information. Accurate encoding and retrieval of affective information and linkage of this experience to events and cues in memory are particularly important because they contribute to motivational states and provide information utilized for adaptive decision-making. The current research plan focuses on developing behavioral and functional imaging paradigms to assess basic memory processes that encode and recognize affective information. The proposed career development and research plans are designed to prepare the candidate to: a) design theoretically-driven tasks to probe utilization of affective information in memory, and b) use these tasks to investigate dysfuntion in neural circuitry involved in emotional and mnemonic function in individuals with schizophrenia. To achieve these goals, the candidate will pursue career development activities which focus on a) advanced training and consultation with experts in affective and cognitive neuroscience to inform assessment of new cognitive-affective stimuli and tasks, b) education and training in MR physics and advanced statistical methods to support effective use of fMRI data acquisition techniques and image analysis, and c) consultation with expert clinical affective and cognitive neuroscientists to enable sophisticated analysis and interpretation of behavioral and neuroimaging data in patient populations. Dr. John Sweeney mentors this project, with significant participation by consultants in affective neuroscience, clinical neuroscience, MR physics, and advanced statistical analysis. This training will enable the candidate to effectively integrate strategies used in affective and cognitive neuroscience paradigms to investigate deficits in affective-cognitive processes in schizophrenia, and to develop the skills and expertise necessary to continue this important line of research as an independent investigator.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
1K23MH067223-01A1
Application #
6720806
Study Section
Special Emphasis Panel (ZRG1-BDCN-2 (02))
Program Officer
Wynne, Debra K
Project Start
2004-01-01
Project End
2008-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
1
Fiscal Year
2004
Total Cost
$149,796
Indirect Cost
Name
University of Illinois at Chicago
Department
Psychiatry
Type
Schools of Medicine
DUNS #
098987217
City
Chicago
State
IL
Country
United States
Zip Code
60612
Olsen, Emily K; Bjorkquist, Olivia A; Bodapati, Anjuli S et al. (2015) Associations between trait anhedonia and emotional memory deficits in females with schizophrenia versus major depression. Psychiatry Res 230:323-30
Nelson, Brady D; Bjorkquist, Olivia A; Olsen, Emily K et al. (2015) Schizophrenia symptom and functional correlates of anterior cingulate cortex activation to emotion stimuli: An fMRI investigation. Psychiatry Res 234:285-91
Bodapati, Anjuli S; Herbener, Ellen S (2014) The impact of social content and negative symptoms on affective ratings in schizophrenia. Psychiatry Res 218:25-30
Bjorkquist, Olivia A; Herbener, Ellen S (2013) Social perception in schizophrenia: evidence of temporo-occipital and prefrontal dysfunction. Psychiatry Res 212:175-82
Strauss, Gregory P; Herbener, Ellen S (2011) Patterns of emotional experience in schizophrenia: differences in emotional response to visual stimuli are associated with clinical presentation and functional outcome. Schizophr Res 128:117-23
Herbener, Ellen S (2009) Impairment in long-term retention of preference conditioning in schizophrenia. Biol Psychiatry 65:1086-90
Baslet, Gaston; Termini, Lindsay; Herbener, Ellen (2009) Deficits in emotional awareness in schizophrenia and their relationship with other measures of functioning. J Nerv Ment Dis 197:655-60
Herbener, Ellen S; Song, Woojin; Khine, Tin T et al. (2008) What aspects of emotional functioning are impaired in schizophrenia? Schizophr Res 98:239-46
Herbener, Ellen S (2008) Emotional memory in schizophrenia. Schizophr Bull 34:875-87
Herbener, Ellen S; Rosen, Cherise; Khine, Tin et al. (2007) Failure of positive but not negative emotional valence to enhance memory in schizophrenia. J Abnorm Psychol 116:43-55

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