The overall goal of this 5-year career development award is to facilitate Colin Depp, Ph.D.'s transition to an independent investigator in late-life bipolar disorder, focusing on psychosocial interventions and medication adherence. Dr. Depp is an NIMH-funded T32 fellow at the University of California, San Diego (UCSD). His research background is in clinical geropsychology, and he has authored over 30 manuscripts (published, in press, or submitted) related to clinical aging issues. During his fellowship, Dr. Depp has investigated late-life bipolar disorder, completing a number of studies in this neglected research arena. Findings from this research indicate that there is a major unmet need for adjunctive psychosocial treatments that are tailored for these patients. Given the importance of medication adherence to treatment of bipolar disorder, and the unique factors related to adherence among older adults (e.g., cognitive impairment), Dr. Depp developed and piloted an intervention to enhance adherence in this group. To develop a trajectory toward becoming an independent intervention researcher in aging, bipolar disorder, and medication adherence, Dr. Depp's career development goals are: 1) to gain a foundation in the treatment of older persons with bipolar disorder and expertise in medication adherence assessment and interventions, 2) to become proficient in designing and conducting ethically-sound clinical trials in this population, and 3) to investigate the relationship of neurocognitive impairments to medication non-adherence to inform future interventions. The proposed training plan will include formal coursework and mentorship from local and national experts in geriatric psychopharmacology, bipolar disorder, medication adherence assessment and interventions, and cognitive science. The training plan is complemented by a research project involving a six-month clinical trial of 90 older persons, who will be randomized to a Medication Adherence Skills Training intervention for bipolar disorder (MAST-BD) (n=45) or a supportive intervention condition (n=45). The MAST-BD intervention, to be further developed through the training plan, combines age-adapted educational, motivational, and medication management components. This research project and training plan will assist the candidate's development from post-doctoral fellow to an independent investigator at UCSD, providing the foundation for a long-term research program focused on improving treatment of bipolar disorder in older adults.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Mentored Patient-Oriented Research Career Development Award (K23)
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Study Section
Interventions Committee for Disorders Related to Schizophrenia, Late Life, or Personality (ITSP)
Program Officer
Chavez, Mark
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University of California San Diego
Schools of Medicine
La Jolla
United States
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Depp, Colin A; Moore, Raeanne C; Dev, Sheena I et al. (2016) The temporal course and clinical correlates of subjective impulsivity in bipolar disorder as revealed through ecological momentary assessment. J Affect Disord 193:145-50
Kaufmann, Christopher N; Gershon, Anda; Eyler, Lisa T et al. (2016) Clinical significance of mobile health assessed sleep duration and variability in bipolar disorder. J Psychiatr Res 81:152-9
Depp, Colin A; Mausbach, Brent T; Harmell, Alexandrea L et al. (2012) Meta-analysis of the association between cognitive abilities and everyday functioning in bipolar disorder. Bipolar Disord 14:217-26
Shepherd, Sally; Depp, Colin A; Harris, Gloria et al. (2012) Perspectives on schizophrenia over the lifespan: a qualitative study. Schizophr Bull 38:295-303
Depp, C A; Savla, G N; de Dios, L A Vergel et al. (2012) Affective symptoms and intra-individual variability in the short-term course of cognitive functioning in bipolar disorder. Psychol Med 42:1409-16
Depp, Colin A; Kim, Daniel H; de Dios, Laura Vergel et al. (2012) A Pilot Study of Mood Ratings Captured by Mobile Phone Versus Paper-and-Pencil Mood Charts in Bipolar Disorder. J Dual Diagn 8:326-332
Depp, Colin A; Mausbach, Brent T; Bowie, Christopher et al. (2012) Determinants of occupational and residential functioning in bipolar disorder. J Affect Disord 136:812-8
Mausbach, Brent T; Depp, Colin A; Bowie, Christopher R et al. (2011) Sensitivity and specificity of the UCSD Performance-based Skills Assessment (UPSA-B) for identifying functional milestones in schizophrenia. Schizophr Res 132:165-70
Depp, Colin A; Cardenas, Veronica; Harris, Sara et al. (2011) Psychopathological and functional correlates of behavioral activation and avoidance in schizophrenia. J Nerv Ment Dis 199:861-5
Depp, Colin; Vahia, Ipsit V; Jeste, Dilip (2010) Successful aging: focus on cognitive and emotional health. Annu Rev Clin Psychol 6:527-50

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