This Mentored Patient-Oriented Research Career Development Award will support the candidate in laying the foundation for a programmatic line of research developing psychosocial treatments for patients with comorbid mood disorders and chronic pain in primary care, testing them in real world settings, and integrating them into usual clinical practice. Mood disorders and chronic pain are highly prevalent and frequently comorbid. Major depression and chronic pain are both leading causes of disability in the US. Depression predicts the onset and persistence of pain, and reciprocally, pain increases risk for onset and severity of depression. Patients with comorbid depression and pain have poorer responses to treatments for depression and for pain. Yet no psychosocial treatments have been developed and prospectively tested specifically for patients with mood disorders like depression and chronic pain. Further, many patients with mood disorders and chronic pain, particularly low-income patients, seek care from their primary care physicians. This suggests that primary care settings present an excellent opportunity for treating this population of patients. The proposed study aims to refine and test a psychosocial intervention designed to be administered in primary care settings for the treatment of comorbid mood disorders and chronic pain, Interpersonal Therapy for Depression and Pain (IPT-P). The proposal includes intensive multidisciplinary mentoring toward developing skills in: measuring comorbid depression and pain and identifying moderators of clinical course;designing and implementing randomized clinical trials;and conducting research with low- income and minority individuals. Detailed formal coursework, site visits, and targeted consultation complete the educational plan. The proposed project is a two-phase study and operationalizes mood disorders as major depression and chronic pain as chronic pelvic pain. In Phase 1, IPT-P will be piloted with 15 low- income gynecology patients with major depression and chronic pelvic pain. The findings will be used to refine the treatment, assessment, and therapist training procedures and finalize the manual. In Phase 2, a randomized controlled trial with 60 patients will be conducted to: 1) assess feasibility, adherence, and acceptability of IPT-P;2) generate effect sizes for a full-scale randomized controlled trial;and 3) compare IPT-P to treatment as usual in decreasing depressive symptoms and improving secondary outcomes among women's health patients with major depression and chronic pelvic pain. The educational and research activities will provide the candidate with the skills and expertise needed to launch a systematic program of research aimed at developing and implementing effective psychosocial treatments for patients with mood disorders and comorbid pain in primary care settings. These treatments will contribute to the efforts needed to reduce the suffering and expense caused by the deleterious impact of comorbid mood disorders and pain.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Mentored Patient-Oriented Research Career Development Award (K23)
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Study Section
Interventions Committee for Adult Mood and Anxiety Disorders (ITMA)
Program Officer
Chavez, Mark
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University of Rochester
Schools of Dentistry
United States
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Poleshuck, Ellen L; Gamble, Stephanie A; Bellenger, Kelly et al. (2014) Randomized controlled trial of interpersonal psychotherapy versus enhanced treatment as usual for women with co-occurring depression and pelvic pain. J Psychosom Res 77:264-72
Poleshuck, Ellen L; Cerrito, Beth; Leshoure, Nicole et al. (2013) Underserved women in a women's health clinic describe their experiences of depressive symptoms and why they have low uptake of psychotherapy. Community Ment Health J 49:50-60
Gamble, Stephanie A; Talbot, Nancy L; Cashman-Brown, Sarah M et al. (2013) A pilot study of interpersonal psychotherapy for alcohol-dependent women with co-occurring major depression. Subst Abus 34:233-41
Poleshuck, Ellen L; Talbot, Nancy L; Moynihan, Jan A et al. (2013) Depressive symptoms, pain, chronic medical morbidity, and interleukin-6 among primary care patients. Pain Med 14:686-91
Cerulli, Catherine; Poleshuck, Ellen; Raimondi, Christina et al. (2012) ""What Fresh Hell Is This?"" Victims of Intimate Partner Violence Describe Their Experiences of Abuse, Pain, and Depression. J Fam Violence 27:773-781
Gamble, Stephanie A; Smith, Phillip N; Poleshuck, Ellen L et al. (2011) Domain-specific social functioning improvements during treatment of depressed women with histories of childhood sexual abuse. J Affect Disord 130:478-82
Poleshuck, Ellen L; Talbot, Nancy E; Zlotnick, Caron et al. (2010) Interpersonal psychotherapy for women with comorbid depression and chronic pain. J Nerv Ment Dis 198:597-600
Poleshuck, Ellen L; Gamble, Stephanie A; Cort, Natalie et al. (2010) Interpersonal Psychotherapy for Co-occurring Depression and Chronic Pain. Prof Psychol Res Pr 41:312-318
Poleshuck, Ellen L; Bair, Matthew J; Kroenke, Kurt et al. (2010) Musculoskeletal pain and measures of depression: response to comment on the article by Poleshuck et al. Gen Hosp Psychiatry 32:114-5
Poleshuck, Ellen L; Talbot, Nancy L; Su, Haiyan et al. (2009) Pain as a predictor of depression treatment outcomes in women with childhood sexual abuse. Compr Psychiatry 50:215-20

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