The goal of the proposed research is to assess new strategies for partner management and STI control as methods to reduce the spread of HIV-1 among men who have sex with men (MSM) in Latin America. The HIV epidemic in Peru remains concentrated within the core risk group of MSM. STI infection and re-infection are central to the continuation of the HIV epidemic among MSM in Peru. Development of improved strategies for partner notification and treatment will reduce the incidence and prevalence of STIs and ultimately reduce the incidence of HIV infection in this population.
Specific Aim 1 : To explore the influence of behavioral, sociocultural, and clinical aspects of STI transmission on partner notification attitudes and practices among MSM in urban Peru.
Specific Aim 1 a. To develop a quantitative survey for the assessment of behavioral, sociocultural, and biomedical factors influencing partner notification decisions among MSM in Peru.
Specific Aim 1 b. To use quantitative methods to assess behavioral, sociocultural, and biomedical factors influencing partner notification decisions among MSM in Peru.
Specific Aim 2 : To assess the efficacy of internet- and referral card-based partner notification tools for the improvement of partner notification outcomes among MSM in Lima, Peru. The intervention is tailored to address key aspects of Peru's social and epidemiologic environment, including high rates of internet use, underdeveloped community formation among MSM, and circular patterns of HIV and STI transmission within MSM sexual networks. As a result, the proposed research manipulates existing mechanisms and patterns of interaction for the spread of HIV/STIs among MSM to design innovative, cost-effective systems of partner notification for the prevention of STI and HIV transmission in Peru. PUBLI

Public Health Relevance

Partner notification and treatment are critical, unresolved aspects of HIV and STI control in both developed and developing regions. The strategies assessed here, while organic to the specific needs of the HIV epidemic in Latin America, will be applicable to a wide range of global settings to increase control of STIs and prevent the transmission of HIV infection.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Mentored Patient-Oriented Research Career Development Award (K23)
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Behavioral and Social Science Approaches to Preventing HIV/AIDS Study Section (BSPH)
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Pequegnat, Willo
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University of California Los Angeles
Internal Medicine/Medicine
Schools of Medicine
Los Angeles
United States
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Vagenas, Panagiotis; Brown, Shan-Estelle; Clark, Jesse L et al. (2017) A Qualitative Assessment of Alcohol Consumption and Sexual Risk Behaviors Among Men Who Have Sex With Men and Transgender Women in Peru. Subst Use Misuse 52:831-839
Braun, Hannan M; Segura, Eddy R; Lake, Jordan E et al. (2017) Individual and partnership factors associated with anticipated versus actual partner notification following STI diagnosis among men who have sex with men and/or with transgender women in Lima, Peru. Sex Transm Infect :
Satcher, Milan F; Segura, Eddy R; Silva-Santisteban, Alfonso et al. (2017) Partner-Level Factors Associated with Insertive and Receptive Condomless Anal Intercourse Among Transgender Women in Lima, Peru. AIDS Behav 21:2439-2451
Clark, Jesse L; Segura, Eddy R; Oldenburg, Catherine E et al. (2017) Expedited Partner Therapy (EPT) increases the frequency of partner notification among MSM in Lima, Peru: a pilot randomized controlled trial. BMC Med 15:94
Delgado, Jeanne R; Segura, Eddy R; Lake, Jordan E et al. (2017) Event-level analysis of alcohol consumption and condom use in partnership contexts among men who have sex with men and transgender women in Lima, Peru. Drug Alcohol Depend 170:17-24
Perez-Brumer, Amaya G; Oldenburg, Catherine E; Segura, Eddy R et al. (2016) Anonymous partnerships among MSM and transgender women (TW) recently diagnosed with HIV and other STIs in Lima, Peru: an individual-level and dyad-level analysis. Sex Transm Infect :
Clark, Jesse L; Perez-Brumer, Amaya G; Segura, Eddy R et al. (2016) Anticipated Notification of Sexual Partners following STD Diagnosis among Men Who Have Sex with Men and Transgender Women in Lima, Peru: A Mixed Methods Analysis. PLoS One 11:e0163905
Blair, CherĂ­e S; Segura, Eddy R; Perez-Brumer, Amaya G et al. (2016) Sexual Orientation, Gender Identity and Perceived Source of Infection Among Men Who Have Sex with Men (MSM) and Transgender Women (TW) Recently Diagnosed with HIV and/or STI in Lima, Peru. AIDS Behav 20:2178-2185
Cambou, Mary C; Luz, Paula M; Lake, Jordan E et al. (2015) Anal human papillomavirus (HPV) prevalences and factors associated with abnormal anal cytology in HIV-infected women in an urban cohort from Rio de Janeiro, Brazil. AIDS Patient Care STDS 29:4-12
Clark, Jesse L; Perez-Brumer, Amaya; Salazar, Ximena (2015) ""Manejar la Situacion"": Partner Notification, Partner Management, and Conceptual Frameworks for HIV/STI Control Among MSM in Peru. AIDS Behav 19:2245-54

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