In this application for a Mentored Patient-Oriented Research Career Development Award (K-23), the candidate proposes to develop expertise in the study of emotion regulation among elders with Major Depressive Disorder (MDD). The research component of this application focuses on the effectiveness of two conscious emotion regulation strategies - reappraisal and distraction - in modulating positive and negative affect in individuals age 65+with or without MDD. Effectiveness will be assessed using both behavioral and neuroimaging experimental techniques. The candidate training plan involves focused, mentored training aimed at integrating: 1) The study of emotion regulation;2) Etiology, symptoms, and course of late-life MDD;3) Neurocognitive contributions to emotion regulation;and 4) The use of basic experimental data to inform treatment development. To establish a career as a productive and independent investigator with a specialty in the mechanisms of emotion regulation in late-life MDD, the applicant is seeking support to obtain training in the disciplines listed above. This proposal is based on the hypothesis that despite neurologically-based changes in emotion regulation abilities associated with both normal aging and MDD, structured training in emotion regulation techniques can help to ameliorate negative affect associated with external and internal stressors in this population. Building upon the training outlined in this award proposal, the candidate will undertake a set of behavioral and fMRI-based studies to investigate both the neural mechanisms underlying emotion regulation as well as the effectiveness of specific emotion regulation strategies in older adults with MDD. A follow-up study will examine the relationship between emotion regulation abilities and both cognitive and symptom status one year after testing. This translational research program will extend existing knowledge by innovatively integrating work in basic emotions, geriatrics, and psychopathology. In addition to helping establish the candidate's career in the study of emotion regulation in affective disorders, this line of research has the potential to inform improved and novel interventions for late-life MDD.

Public Health Relevance

MDD is a costly and burdensome condition that affects a significant proportion of elders. The series of proposed studies will shed light on ways that depressed older adults can manage their negative emotions. The findings of these studies may lead to the future development of psychotherapeutic interventions targeting mood symptoms in late-life MDD.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Mentored Patient-Oriented Research Career Development Award (K23)
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National Institute on Aging Initial Review Group (NIA)
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Chavez, Mark
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Duke University
Schools of Medicine
United States
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Smoski, Moria J; LaBar, Kevin S; Steffens, David C (2014) Relative effectiveness of reappraisal and distraction in regulating emotion in late-life depression. Am J Geriatr Psychiatry 22:898-907
Paul, Natalie A; Stanton, Steven J; Greeson, Jeffrey M et al. (2013) Psychological and neural mechanisms of trait mindfulness in reducing depression vulnerability. Soc Cogn Affect Neurosci 8:56-64
Schiller, Crystal Edler; Minkel, Jared; Smoski, Moria J et al. (2013) Remitted major depression is characterized by reduced prefrontal cortex reactivity to reward loss. J Affect Disord 151:756-62
Smoski, Moria J; Keng, Shian-Ling; Schiller, Crystal Edler et al. (2013) Neural mechanisms of cognitive reappraisal in remitted major depressive disorder. J Affect Disord 151:171-7
Addicott, Merideth A; Baranger, David A A; Kozink, Rachel V et al. (2012) Smoking withdrawal is associated with increases in brain activation during decision making and reward anticipation: a preliminary study. Psychopharmacology (Berl) 219:563-73
Dichter, Gabriel S; Kozink, Rachel V; McClernon, F Joseph et al. (2012) Remitted major depression is characterized by reward network hyperactivation during reward anticipation and hypoactivation during reward outcomes. J Affect Disord 136:1126-34
Smoski, Moria J; Rittenberg, Alison; Dichter, Gabriel S (2011) Major depressive disorder is characterized by greater reward network activation to monetary than pleasant image rewards. Psychiatry Res 194:263-70
Keng, Shian-Ling; Smoski, Moria J; Robins, Clive J (2011) Effects of mindfulness on psychological health: a review of empirical studies. Clin Psychol Rev 31:1041-56
Dichter, Gabriel S; Felder, Jennifer N; Smoski, Moria J (2010) The effects of Brief Behavioral Activation Therapy for Depression on cognitive control in affective contexts: An fMRI investigation. J Affect Disord 126:236-44
Dichter, Gabriel S; Felder, Jennifer N; Petty, Christopher et al. (2009) The effects of psychotherapy on neural responses to rewards in major depression. Biol Psychiatry 66:886-97