Young men of color who have sex with men (YMCSM, ages 13-29) experience the highest rates of new HIV infections in the U.S., with existing prevention interventions failing to reach most of this hard to reach population. Recent developments in HIV prevention, however, hold promise to help reverse the trend of rising HIV rates in YMCSM, as well as the overall burden of HIV. Pre-exposure prophylaxis (PrEP), an oral antiretroviral regimen taken daily by HIV-uninfected individuals to prevent HIV acquisition, has demonstrated efficacy for reducing HIV acquisition risk in multiple high-risk populations. At the same time, increasingly ubiquitous use of social media (e.g. Facebook, Twitter, online dating sites) by young people, including low- income YMCSM, provides an efficient avenue to identify and reach many otherwise hard to reach YMCSM. The overall goal of this mentored career development award proposal is to develop and pilot-test a social media-based peer-led intervention to promote PrEP uptake in YMCSM. We will use mixed methods and a 'diffusion of innovation' framework to: (1) determine factors associated with interest in and adoption of PrEP among YMCSM; (2) develop Empowering with PrEP (E-PrEP), a social media-based peer-led intervention to increase PrEP uptake in YMCSM; and (3) pilot-test the feasibility and preliminary efficacy of E-PrEP for increasing intention to use and adoption of PrEP by YMCSM. With guidance from a multi-disciplinary team of expert mentors, I will conduct in-person qualitative interviews with users and non-adopters of PrEP to identify current facilitators of and barriers to its uptake. Using the 'diffusion of innovation' theoretical framework to interpret our findings, I ill then partner with YMCSM peer leaders to develop a social media-based intervention to facilitate PrEP uptake. The resulting E-PrEP intervention will use online messaging and discussions directed by peer leaders to provide education on PrEP, increase interest in PrEP use, and facilitate access to PrEP. We will then conduct a pilot randomized trial of E-PrEP (versus exposure to online messaging and discussions promoting general health and nutrition) in YMCSM ages 18-29 to assess E-PrEP's feasibility and preliminary efficacy for increasing self-reported intention in and uptake of PrEP among YMCSM. We hypothesize that, compared to a control group exposed to non-overlapping online contents focused on general health topics, participants randomized to E-PrEP will be more likely to express intention to use and to use PrEP. Once we have preliminarily determined an effect size for E-PrEP's efficacy, we will submit an R01 application to test E-PrEP among YMCSM in a multi-center randomized trial. During the award period, I will develop expertise in social media- and technology-based health interventions, including associated ethical challenges, and I will also pursue advanced training in longitudinal and qualitative data analysis. Completion of my planned research and career development activities will allow me to become an independent investigator of novel bio-behavioral interventions for improving the health of hard to reach populations.

Public Health Relevance

Young men of color who have sex with men (YMCSM) in the U.S. experience the highest rates of new HIV infections, with existing prevention interventions failing to reach most of this hard to reach population. Pre- exposure prophylaxis (PrEP), an oral antiretroviral medication taken daily by HIV-uninfected individuals, has shown efficacy in preventing HIV. At the same time, increasingly widespread use of social media (e.g. Facebook, online dating sites) by young people, including YMCSM, provides an efficient avenue to identify and reach large populations of high-risk individuals and to rapidly disseminate information about effective HIV prevention tools. This study uses a community based participatory research approach to identify factors impacting PrEP adoption and design and implement a social media-based peer-led intervention to enhance uptake of this new biomedical innovation for HIV prevention. Results will have the potential to enhance PrEP uptake, reduce HIV transmission, and improve health outcomes among hard to reach populations.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
6K23MH102118-03
Application #
9134378
Study Section
Behavioral and Social Science Approaches to Preventing HIV/AIDS Study Section (BSPH)
Program Officer
Allison, Susannah
Project Start
2014-09-23
Project End
2019-06-30
Budget Start
2015-09-01
Budget End
2016-06-30
Support Year
3
Fiscal Year
2015
Total Cost
$184,734
Indirect Cost
$13,684
Name
Albert Einstein College of Medicine
Department
Type
DUNS #
079783367
City
Bronx
State
NY
Country
United States
Zip Code
10461
Bien, Cedric H; Patel, Viraj V; Blackstock, Oni J et al. (2016) Reaching Key Populations: PrEP Uptake in an Urban Health Care System in the Bronx, New York. AIDS Behav :
Blackstock, Oni J; Moore, Brent A; Berkenblit, Gail V et al. (2016) A Cross-Sectional Online Survey of HIV Pre-Exposure Prophylaxis Adoption Among Primary Care Physicians. J Gen Intern Med :
Jennifer Edelman, E; Moore, Brent A; Calabrese, Sarah K et al. (2016) Primary Care Physicians' Willingness to Prescribe HIV Pre-exposure Prophylaxis for People who Inject Drugs. AIDS Behav :
Patel, Viraj V; Masyukova, Mariya; Sutton, Desmond et al. (2016) Social Media Use and HIV-Related Risk Behaviors in Young Black and Latino Gay and Bi Men and Transgender Individuals in New York City: Implications for Online Interventions. J Urban Health 93:388-99
Blackstock, Oni J; Patel, Viraj V; Cunningham, Chinazo O (2015) Use of Technology for HIV Prevention Among Adolescent and Adult Women in the United States. Curr HIV/AIDS Rep 12:489-99