The purpose of this K23 is to provide support for the candidate to acquire the skills necessary to conduct patient-oriented research on novel treatments for pain and co-morbid psychiatric disorders. Chronic pain represents a huge public health concern and is generally poorly understood at a basic neurobiological level. There is a lack of individuals with adequate training in the neurobiology of pain who also have the skills to perform high quality clinical evaluations of new treatments. The candidate wishes support for training to become a clinical translational scientist with specific expertise in evaluating novel treatments that will serve as the foundation for his career as a leader in the development and evaluation of new somatic or device-based treatments for chronic pain. The candidate will become familiar with new treatments such as transcranial magnetic stimulation (TMS), vagus nerve stimulation, and deep brain stimulation. The training aspects of the Award will focus on increasing the candidate's knowledge regarding functional neuroanatomy, empirical and theoretical mechanisms of pain, and technology-based treatments. Building on this foundation, the research project will focus on investigating the effects of TMS on pain perception. Previous research suggests that TMS may reduce pain in healthy adults and clinical samples. However, there is relatively little systematic research on TMS and pain that addresses optimal TMS device parameters, optimal cortical targets, and potential differences in response to TMS between healthy subjects and chronic pain populations.
The Specific Aims of the research project are to: 1) Test for replication, findings that stimulation of the motor cortex with TMS results in changes in pain perception and investigate the duration of analgesic effect;2) Determine the TMS device parameters that are associated with the largest changes in acute pain perception to controlled laboratory pain stimuli;3) Determine which TMS cortical targets are associated with the largest changes in pain perception;and 4) Determine if findings from the laboratory investigations generalize to patients with trigeminal neuralgia. Building on the candidate's knowledge base in clinical psychology, statistics, psychophysiology and computer programming, the proposed training program and research project will help the candidate develop into an innovative and critical expert in developing and evaluating new treatments for pain.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Mentored Patient-Oriented Research Career Development Award (K23)
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Study Section
NST-2 Subcommittee (NST)
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Porter, Linda L
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Medical University of South Carolina
Schools of Medicine
United States
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Borckardt, Jeffrey J; Bikson, Marom; Frohman, Heather et al. (2012) A pilot study of the tolerability and effects of high-definition transcranial direct current stimulation (HD-tDCS) on pain perception. J Pain 13:112-20
Borckardt, Jeffrey J; Reeves, Scott T; Frohman, Heather et al. (2011) Fast left prefrontal rTMS acutely suppresses analgesic effects of perceived controllability on the emotional component of pain experience. Pain 152:182-7
Borckardt, Jeffrey J; Reeves, Scott T; Beam, Will et al. (2011) A randomized, controlled investigation of motor cortex transcranial magnetic stimulation (TMS) effects on quantitative sensory measures in healthy adults: evaluation of TMS device parameters. Clin J Pain 27:486-94
McFadden, James L; Borckardt, Jeff J; George, Mark S et al. (2011) Reducing procedural pain and discomfort associated with transcranial direct current stimulation. Brain Stimul 4:38-42
Roberts, Donna R; Ramsey, David; Johnson, Kevin et al. (2010) Cerebral cortex plasticity after 90 days of bed rest: data from TMS and fMRI. Aviat Space Environ Med 81:30-40
Nahas, Ziad; Anderson, Berry S; Borckardt, Jeff et al. (2010) Bilateral epidural prefrontal cortical stimulation for treatment-resistant depression. Biol Psychiatry 67:101-9
Borckardt, Jeffrey J; Reeves, Scott; George, Mark S (2009) The potential role of brain stimulation in the management of postoperative pain. J Pain Manag 2:295-300
Beam, William; Borckardt, Jeffrey J; Reeves, Scott T et al. (2009) An efficient and accurate new method for locating the F3 position for prefrontal TMS applications. Brain Stimul 2:50-4
Anderson, Berry S; Kavanagh, Katie; Borckardt, Jeffrey J et al. (2009) Decreasing procedural pain over time of left prefrontal rTMS for depression: initial results from the open-label phase of a multi-site trial (OPT-TMS). Brain Stimul 2:88-92
Borckardt, Jeffrey J; Linder, Katherine J; Ricci, Raffaella et al. (2009) Focal electrically administered therapy: device parameter effects on stimulus perception in humans. J ECT 25:91-8

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