The candidate, Michael S. Cartwright, MD is a junior neurologist with experience using neuromuscular ultrasound in clinical and research settings. In June 2008 he completed a Clinical Research Training Grant from the MDA, during which he received training in epidemiology, research design, and biostatistical methods. This will provide him with a solid foundation for clinical research, but to develop as a translational researcher he requires training in the basic science of medical imaging and experience with longitudinal patient-oriented studies. During the award period, Dr. Cartwright will be mentored by two individuals with complementary experience in medical imaging. Dr. Francis Walker is an international expert in neuromuscular ultrasound, and Dr. Peter Santago is a biomedical engineer with expertise in the basic science of medical imaging. In addition, Dr. Cartwright will take medical imaging graduate level courses at the Virginia Tech-Wake Forest School of Biomedical Engineering. The research plan is designed to highlight the importance of neuromuscular ultrasound in the diagnostic evaluation of individuals with focal neuropathies and to provide Dr. Cartwright with experience organizing and conducting a clinical trial. The first component of the study will demonstrate the validity and reliability of neuromuscular ultrasound. The second component is a double-masked randomized clinical trial to assess the efficacy of diagnostic ultrasound on the functional outcomes of 150 individuals with focal neuropathies. The hypothesis driving the second component of the study is that individuals diagnosed with a focal neuropathy by a combination of electrodiagnostic studies and ultrasound will have a more refined and accurate diagnosis, will be referred for appropriate treatment more often, and will, therefore, have better functional outcomes compared to those evaluated with traditional electrodiagnostic studies alone.

Public Health Relevance

Focal neuropathies affect more than 300,000 individuals each year in the United States and medical costs exceed $500 million annually. During this career development award, Dr. Cartwright will acquire the knowledge and skills necessary to bring sophisticated neuromuscular imaging technologies from the developmental stage into the realm of patient care, and the research plan will test if diagnostic ultrasound can lead to improved functional outcomes in individuals with focal neuropathies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23NS062892-04
Application #
8274681
Study Section
NST-2 Subcommittee (NST)
Program Officer
Gwinn, Katrina
Project Start
2009-06-01
Project End
2014-05-31
Budget Start
2012-06-01
Budget End
2013-05-31
Support Year
4
Fiscal Year
2012
Total Cost
$134,214
Indirect Cost
$9,942
Name
Wake Forest University Health Sciences
Department
Neurology
Type
Schools of Medicine
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157
Martin, Matthew J; Cartwright, Michael S (2016) A Pilot Study of Strain Elastography in the Diagnosis of Carpal Tunnel Syndrome. J Clin Neurophysiol :
Cartwright, Michael S; Yeboah, Samuel; Walker, Francis O et al. (2016) Examining the association between musculoskeletal injuries and carpal tunnel syndrome in manual laborers. Muscle Nerve 54:31-5
Caress, James B; Ciarlone, Stephanie L; Sullivan, Elizabeth A et al. (2016) Natural history of muscle cramps in amyotrophic lateral sclerosis. Muscle Nerve 53:513-7
Shen, Jack; Cartwright, Michael S (2016) Neuromuscular Ultrasound in the Assessment of Polyneuropathies and Motor Neuron Disease. J Clin Neurophysiol 33:86-93
Arcury, Thomas A; Chen, Haiying; Mora, Dana C et al. (2016) The effects of work organization on the health of immigrant manual workers: A longitudinal analysis. Arch Environ Occup Health 71:66-73
Tawfik, Eman A; Walker, Francis O; Cartwright, Michael S (2015) A Pilot Study of Diagnostic Neuromuscular Ultrasound in Bell's Palsy. J Neuroimaging 25:564-70
Sarwal, Aarti; Parry, Selina M; Berry, Michael J et al. (2015) Interobserver Reliability of Quantitative Muscle Sonographic Analysis in the Critically Ill Population. J Ultrasound Med 34:1191-200
Cartwright, Michael S; Dupuis, Janae E; Bargoil, Jessica M et al. (2015) Can a combination of ultrasonographic parameters accurately evaluate concussion and guide return-to-play decisions? Med Hypotheses 85:262-5
Feng, Xin; Cartwright, Michael S; Walker, Francis O et al. (2015) Ultrasonographic evaluation of geniohyoid muscle and hyoid bone during swallowing in young adults. Laryngoscope 125:1886-91
Sarwal, Aarti; Liu, Ann; Cartwright, Michael S et al. (2015) Sonography for Assessing Dynamic Diaphragm Dysfunction in Acute Respiratory Distress. J Ultrasound Med 34:1701-6

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