Patient-oriented research is an important part of the NIH mission. The K24 funding mechanism provides an outstanding opportunity to provide mentoring opportunities for new or future clinical researchers while at the same time enhancing the mentor's own patient-oriented research program. The Candidate has a long and strong history in mentoring;she is a nationally-recognized leader in the alcohol research field;and she has a consistent track record in acquisition of peer-reviewed funding. Great progress was made in the initial funding period, consistent with the goals of the K24. This application represents a request for a second five years of support. The Candidate's long-term career goal is to provide quality mentoring in patient-oriented research to the next generation of alcohol researchers while, at the same time, becoming an expert in patient-oriented research focused on the relationship between social anxiety and alcohol. The environment for patient-oriented research and the resources at the Medical University of South Carolina (MUSC) are outstanding. Examples of opportunities for mentees include participation in multisite and investigator-initiated pharmacotherapy clinical trials with new medications for alcohol treatment;pharmacogenomic studies to begin to predict drug response;human laboratory studies of voluntary drinking to study medication effects;gender-related research related to relapse;and studies of the relationship between stress and drinking. The MUSC Charleston Alcohol Research Center, the Women's Research Center, and the Neurobiology of Addiction Research Center together provide a stimulating multidisciplinary academic environment for all mentees and help facilitate patient-oriented and translational research. The Candidate has demonstrated the ability to attract strong mentees and to develop them into independent clinical researchers. These individuals remain in academic careers and, importantly, continue to conduct alcohol research. The Candidate's research program and the Charleston Alcohol Research Center's theme relate to the important problem of alcohol treatment, a research area of major importance to society.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
Application #
Study Section
Health Services Research Review Subcommittee (AA)
Program Officer
Roach, Deidra
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Medical University of South Carolina
Schools of Medicine
United States
Zip Code
Book, Sarah W; Thomas, Suzanne E; Smith, Joshua P et al. (2012) Severity of anxiety in mental health versus addiction treatment settings when social anxiety and substance abuse are comorbid. Addict Behav 37:1158-61
Smith, Joshua P; Book, Sarah W (2010) Comorbidity of generalized anxiety disorder and alcohol use disorders among individuals seeking outpatient substance abuse treatment. Addict Behav 35:42-5
Tonigan, J Scott; Book, Sarah W; Pagano, Maria E et al. (2010) 12-Step Therapy and Women with and without Social Phobia: A Study of the Effectiveness of 12-Step Therapy to Facilitate AA Engagement. Alcohol Treat Q 28:151-162
Book, Sarah W; Thomas, Suzanne E; Dempsey, Jared P et al. (2009) Social anxiety impacts willingness to participate in addiction treatment. Addict Behav 34:474-6
Dempsey, Jared P; Randall, Patrick K; Thomas, Suzanne E et al. (2009) Treatment of social anxiety with paroxetine: mediation of changes in anxiety and depression symptoms. Compr Psychiatry 50:135-41
Carrigan, Maureen H; Ham, Lindsay S; Thomas, Suzanne E et al. (2008) Alcohol outcome expectancies and drinking to cope with social situations. Addict Behav 33:1162-6
Book, Sarah W; Thomas, Suzanne E; Randall, Patrick K et al. (2008) Paroxetine reduces social anxiety in individuals with a co-occurring alcohol use disorder. J Anxiety Disord 22:310-8
Thomas, Suzanne E; Randall, Patrick K; Book, Sarah W et al. (2008) A complex relationship between co-occurring social anxiety and alcohol use disorders: what effect does treating social anxiety have on drinking? Alcohol Clin Exp Res 32:77-84
Veatch, L M; Wright, T M; Randall, C L (2007) Only male mice show sensitization of handling-induced convulsions across repeated ethanol withdrawal cycles. Alcohol Clin Exp Res 31:477-85
Wright, Tara; Myrick, Hugh; Henderson, Scott et al. (2006) Risk factors for delirium tremens: a retrospective chart review. Am J Addict 15:213-9