This application is for a Mid-Career Investigator Award in Patient-Oriented Research (K-24). My goals in this award are to: 1) Increase research productivity in a resource poor setting and 2) Directed mentorship of promising sub-Saharan African students, medical officers, fellows and junior faculty in designing, executing, and publishing outcomes research relevant to resource-poor settings. My research to date has focused on adherence and health outcomes in impoverished HIV+ drug users in San Francisco. This has included NIMH-funded research on the biology of incomplete adherence (NIMH 54907), Directly Observed Depression Treatment to improve depression and HIV treatment outcomes in depressed homeless individuals (NIMH 63011) and a comparison of Modified Directly Observed Therapy vs. Adherence Case Management (NIMH 64388). This domestic program has identified 9 junior investigators who have collectively published 7 first author publications. More recently, I have expanded my research program to Uganda. With pilot R-21 funding from the NIAAA, we are studying adherence, pharmacokinetics and resistance to generic antiretroviral therapy (NIAAA 014784). This expanding international research program has also identified 4 talented junior investigators (2 Ugandan and 2 US investigators) with 2 manuscripts accepted for publication and an additional two in review. The K-24 mechanism is ideally suited to create sufficient protected time to expand this international research program and to provide directed mentorship of these promising investigators. My established relationship with and support of Makerere University in Uganda likely will lead to several additional promising international investigators. Furthermore, this directed goal of expanding international HIV research and mentorship is a priority for my home institution; I have the supportive commitment from my home institution to reduce my clinical and administrative responsibilities to 20% in order to achieve this goal.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
7K24AA015287-05
Application #
7689474
Study Section
Special Emphasis Panel (ZAA1-CC (11))
Program Officer
Roach, Deidra
Project Start
2004-09-27
Project End
2009-08-31
Budget Start
2008-07-01
Budget End
2008-08-31
Support Year
5
Fiscal Year
2007
Total Cost
$32,837
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Kruse, Gina R; Bangsberg, David R; Hahn, Judith A et al. (2014) Tobacco use among adults initiating treatment for HIV infection in rural Uganda. AIDS Behav 18:1381-9
Katz, Ingrid T; Nkala, Busisiwe; Dietrich, Janan et al. (2013) A qualitative analysis of factors influencing HPV vaccine uptake in Soweto, South Africa among adolescents and their caregivers. PLoS One 8:e72094
Katz, Ingrid T; Ybarra, Michele L; Wyatt, Monique A et al. (2013) Socio-cultural and economic antecedents of adolescent sexual decision-making and HIV-risk in rural Uganda. AIDS Care 25:258-64
Horwitz, Russell H; Tsai, Alexander C; Maling, Samuel et al. (2013) No association found between traditional healer use and delayed antiretroviral initiation in rural Uganda. AIDS Behav 17:260-5
Tsai, Alexander C; Weiser, Sheri D; Steward, Wayne T et al. (2013) Evidence for the reliability and validity of the internalized AIDS-related stigma scale in rural Uganda. AIDS Behav 17:427-33
Volpp, Kevin G; Pauly, Mark V; Loewenstein, George et al. (2009) P4P4P: an agenda for research on pay-for-performance for patients. Health Aff (Millwood) 28:206-14
Weiser, Sheri D; Frongillo, Edward A; Ragland, Kathleen et al. (2009) Food insecurity is associated with incomplete HIV RNA suppression among homeless and marginally housed HIV-infected individuals in San Francisco. J Gen Intern Med 24:14-20
Byakika-Tusiime, Jayne; Crane, Johanna; Oyugi, Jessica H et al. (2009) Longitudinal antiretroviral adherence in HIV+ Ugandan parents and their children initiating HAART in the MTCT-Plus family treatment model: role of depression in declining adherence over time. AIDS Behav 13 Suppl 1:82-91
Das-Douglas, Moupali; Riley, Elise D; Ragland, Kathleen et al. (2009) Implementation of the Medicare Part D prescription drug benefit is associated with antiretroviral therapy interruptions. AIDS Behav 13:1-9
Weiser, Sheri D; Bangsberg, David R; Kegeles, Susan et al. (2009) Food insecurity among homeless and marginally housed individuals living with HIV/AIDS in San Francisco. AIDS Behav 13:841-8

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