This is a revised competing renewal proposal for a Midcareer Investigator Award in Patient- Oriented Research (K24) for Christopher M. Callahan, MD. This proposal requests an additional five years of support (Years 06-10). The first five years of funding were successful and the candidate met or exceeded each of the targeted goals for that award. Dr. Callahan is a physician-scientist whose research focuses on improving the clinical care of older adults. His specific research interests are in dementia and late life depression and improving quality of care for these conditions among older adults in primary care settings. Dr. Callahan is a Professor of Medicine at the Indiana University School of Medicine and the founding Director of the Indiana University Center for Aging Research. The purpose of this Award is to allow the candidate to build his capabilities in aging-related patient-oriented research and to support his role as a mentor for junior faculty and to develop his role as mentor for a growing number of """"""""next generation"""""""" mentors. The candidate is proposing to extend the research laboratory at the Center of Aging Research to target a larger segment of the continuum of care, including the nursing facility setting.
The specific aims for years 06-10 of the K24 are to: 1. Train the next generation of physician-scientists and behavioral scientists in patient-oriented research to improve the care provided to older adults across the continuum of care; 2. Exploit existing clinical practice and clinical trial data by combining these data with longitudinal state-level data describing utilization of nursing facility care;and 3. Re-invigorate the candidate's pursuit of R01-type funding in support of clinical trials that expand the targets of the intervention beyond the walls of primary care. Most older adults are cared for in primary care settings and the candidate remains committed to improving care in this setting. However, strategies to improve care for older adults must increasingly take into account other sites of care, such as that provided in nursing facilities and in the patient's home.

Public Health Relevance

The project has two goals. The first goal is to increase the nation's capacity to conduct patient-oriented research by increasing the number of physician-scientists trained in clinical research relevant to older adults. The second goal is to expand the Candidate's scope of research by studying clinical interventions that account for the multiple health care providers and sites of care involved in delivering care to older adults, including nursing facilities.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Application #
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Baker, Colin S
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Indiana University-Purdue University at Indianapolis
Internal Medicine/Medicine
Schools of Medicine
United States
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Khambaty, Tasneem; Callahan, Christopher M; Perkins, Anthony J et al. (2017) Depression and Anxiety Screens as Simultaneous Predictors of 10-Year Incidence of Diabetes Mellitus in Older Adults in Primary Care. J Am Geriatr Soc 65:294-300
Cagle, John G; Unroe, Kathleen T; Bunting, Morgan et al. (2017) Caring for Dying Patients in the Nursing Home: Voices From Frontline Nursing Home Staff. J Pain Symptom Manage 53:198-207
LaMantia, Michael A; Stump, Timothy E; Messina, Frank C et al. (2016) Emergency Department Use Among Older Adults With Dementia. Alzheimer Dis Assoc Disord 30:35-40
Wang, Chenkun; Gao, Sujuan; Hendrie, Hugh C et al. (2016) Antidepressant Use in the Elderly Is Associated With an Increased Risk of Dementia. Alzheimer Dis Assoc Disord 30:99-104
Stewart, Jesse C; Hawkins, Misty A W; Khambaty, Tasneem et al. (2016) Depression and Anxiety Screens as Predictors of 8-Year Incidence of Myocardial Infarction and Stroke in Primary Care Patients. Psychosom Med 78:593-601
Unroe, Kathleen T; Sachs, Greg A; Dennis, M E et al. (2016) Effect of Hospice Use on Costs of Care for Long-Stay Nursing Home Decedents. J Am Geriatr Soc 64:723-30
Callahan, Christopher M; Tu, Wanzhu; Stump, Timothy E et al. (2015) Errors in self-reports of health services use: impact on alzheimer disease clinical trial designs. Alzheimer Dis Assoc Disord 29:75-81
Aggarwal, Himani; Callahan, Christopher M; Miller, Kathy D et al. (2015) Are There Differences in Treatment and Survival Between Poor, Older Black and White Women with Breast Cancer? J Am Geriatr Soc 63:2008-13
Unroe, Kathleen T; Sachs, Greg A; Dennis, M E et al. (2015) Hospice use among nursing home and non-nursing home patients. J Gen Intern Med 30:193-8
Unroe, Kathleen T; Cagle, John G; Lane, Kathleen A et al. (2015) Nursing Home Staff Palliative Care Knowledge and Practices: Results of a Large Survey of Frontline Workers. J Pain Symptom Manage 50:622-9

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