This is an application for a K24 Midcareer Investigator Award in aging-related patient-oriented research. The candidate is an associate professor of psychiatry, neurology and epidemiology at the University of California, San Francisco (UCSF) with an established record as a researcher, clinician, and mentor. The overarching aims of this proposal are to identify cognitive trajectories, their predictors and outcomes among elders in their 9th and 10 decade of life. We propose to conduct our aims from two ongoing NIH-funded prospective studies, the Study of Osteoporotic Fractures (SOF) and the Health Aging and Body Composition Study (Health ABC). We will determine the 10- to 20-year longitudinal trajectories of cognitive function of elders living into their 80's and 90's and to identify the predictors, primarily novel biomarkers, of these cognitive trajectories. In addition, we will determine how these different trajectories influence important health outcomes such as functional status, mortality and nursing home placement. The applicant will use her research as a platform for the mentorship of patient-oriented researchers and will promote a multidisciplinary research approach to cognitive aging. Trainees will participate in research seminars, career development and grant-writing workshops, and in formal didactic training including the K30 Clinical Research Curriculum and the newly funded CTSA program at UCSF. Strengths of the candidate include her formal training in research methods, her history of research productivity and NIH funding including several active R01s, and her early track record of mentoring junior trainees. Strengths of the institution include the resources of the K30 and CTSA, several T32 and K12 training grants from which to garner potential mentees, and the availability of resources to foster research of junior investigators. This award will be instrumental in advancing the applicant's research in the epidemiology of cognitive aging and in mentoring the """"""""next generation"""""""" of investigators committed to cognitive aging patient-oriented research.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24AG031155-04
Application #
7899901
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Wagster, Molly V
Project Start
2007-09-30
Project End
2012-07-31
Budget Start
2010-08-01
Budget End
2011-07-31
Support Year
4
Fiscal Year
2010
Total Cost
$140,961
Indirect Cost
Name
University of California San Francisco
Department
Psychiatry
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Cleret de Langavant, Laurent; Bayen, Eleonore; Yaffe, Kristine (2018) Unsupervised Machine Learning to Identify High Likelihood of Dementia in Population-Based Surveys: Development and Validation Study. J Med Internet Res 20:e10493
Bonham, Luke W; Evans, Daniel S; Liu, Yongmei et al. (2018) Neurotransmitter Pathway Genes in Cognitive Decline During Aging: Evidence for GNG4 and KCNQ2 Genes. Am J Alzheimers Dis Other Demen 33:153-165
Byers, Amy L; Lui, Li-Yung; Vittinghoff, Eric et al. (2018) Burden of Depressive Symptoms Over 2 Decades and Risk of Nursing Home Placement in Older Women. J Am Geriatr Soc 66:1895-1901
Kaup, Allison R; Xia, Feng; Launer, Lenore J et al. (2018) Occupational cognitive complexity in earlier adulthood is associated with brain structure and cognitive health in midlife: The CARDIA study. Neuropsychology 32:895-905
Ward, Michael E; Gelfand, Jeffrey M; Lui, Li-Yung et al. (2018) Reduced contrast sensitivity among older women is associated with increased risk of cognitive impairment. Ann Neurol 83:730-738
Leng, Yue; Goldman, Samuel M; Cawthon, Peggy M et al. (2018) Excessive daytime sleepiness, objective napping and 11-year risk of Parkinson's disease in older men. Int J Epidemiol 47:1679-1686
Kaup, Allison R; Peltz, Carrie; Kenney, Kimbra et al. (2017) Neuropsychological Profile of Lifetime Traumatic Brain Injury in Older Veterans. J Int Neuropsychol Soc 23:56-64
Leng, Yue; McEvoy, Claire T; Allen, Isabel E et al. (2017) Association of Sleep-Disordered Breathing With Cognitive Function and Risk of Cognitive Impairment: A Systematic Review and Meta-analysis. JAMA Neurol 74:1237-1245
Gardner, Raquel C; Langa, Kenneth M; Yaffe, Kristine (2017) Subjective and objective cognitive function among older adults with a history of traumatic brain injury: A population-based cohort study. PLoS Med 14:e1002246
Peltz, Carrie B; Gardner, Raquel C; Kenney, Kimbra et al. (2017) Neurobehavioral Characteristics of Older Veterans With Remote Traumatic Brain Injury. J Head Trauma Rehabil 32:E8-E15

Showing the most recent 10 out of 117 publications